| Journal: | Brazilian journal of medical and biological research |
| Database: | PERIÓDICA |
| System number: | 000350354 |
| ISSN: | 0100-879X |
| Authors: | Argüelles, J1 Díaz, J.J1 Málaga, I1 Perillan, C1 Costales, M1 Vijande, M1 |
| Institutions: | 1Universidad de Oviedo, Hospital Universitario Central de Asturias, Oviedo. España |
| Year: | 2007 |
| Season: | May |
| Volumen: | 40 |
| Number: | 5 |
| Pages: | 721-726 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Popular science has emphasized the risks of high sodium intake and many studies have confirmed that salt intake is closely related to hypertension. The present mini-review summarizes experiments about salt taste sensitivity and its relationship with blood pressure (BP) and other variables of clinical and familial relevance. Children and adolescents from control parents (N = 72) or with at least one essential hypertensive (EHT) parent (N = 51) were investigated. Maternal questionnaires on eating habits and vomiting episodes were collected. Offspring, anthropometric, BP, and salt taste sensitivity values were recorded and blood samples analyzed. Most mothers declared that they added "little salt" when cooking. Salt taste sensitivity was inversely correlated with systolic BP (SBP) in control youngsters (r = -0.33; P = 0.015). In the EHT group, SBP values were similar to control and a lower salt taste sensitivity threshold was found. Obese offspring of EHT parents showed higher SBP and C-reactive protein values but no differences in renin-angiotensin-aldosterone system activity. Salt taste sensitivity was correlated with SBP only in the non-obese EHT group (N = 41; r = 0.37; P = 0.02). Salt taste sensitivity was correlated with SBP in healthy, normotensive children and adolescents whose mothers reported significant vomiting during the first trimester (N = 18; r = -0.66; P < 0.005), but not in "non-vomiter offspring" (N = 54; r = -0.18; nonsignificant). There is evidence for a linkage between high blood pressure, salt intake and sensitivity, perinatal environment and obesity, with potential physiopathological implications in humans. This relationship has not been studied comprehensively using homogeneous methods and therefore more research is needed in this field |
| Disciplines: | Medicina |
| Keyword: | Pediatría, Sistema cardiovascular, Metabolismo, Sodio, Hipertensión arterial, Riesgo cardiovascular, Obesidad, Embarazo |
| Keyword: | Medicine, Cardiovascular system, Pediatrics, Metabolism, Sodium, Arterial hypertension, Cardiovascular risk, Obesity, Pregnancy |
| Full text: | Texto completo (Ver HTML) |
