Journal: | Brazilian journal of medical and biological research |
Database: | PERIÓDICA |
System number: | 000350356 |
ISSN: | 0100-879X |
Authors: | Xue, B1 Johnson, A.K1 Hay, M1 |
Institutions: | 1University of Iowa, Cardiovascular Center, Iowa City, Iowa. Estados Unidos de América |
Year: | 2007 |
Season: | May |
Volumen: | 40 |
Number: | 5 |
Pages: | 727-734 |
Country: | Brasil |
Language: | Inglés |
Document type: | Artículo |
Approach: | Experimental, aplicado |
English abstract | Sex differences in the development of hypertension and cardiovascular disease have been described in humans and in animal models. In this paper we will review some of our studies which have as their emphasis the examination of the role of sex differences and sex steroids in modulating the central actions of angiotensin II (ANG II) via interactions with free radicals and nitric oxide, generating pathways within brain circumventricular organs and in central sympathomodulatory systems. Our studies indicate that low-dose infusions of ANG II result in hypertension in wild-type male mice but not in intact wild-type females. Furthermore, we have demonstrated that ANG II-induced hypertension in males is blocked by central infusions of the androgen receptor antagonist, flutamide, and by central infusions of the superoxide dismutase mimetic, tempol. We have also found that, in comparison to females, males show greater levels of intracellular reactive oxygen species in circumventricular organ neurons following long-term ANG II infusions. In female mice, ovariectomy, central blockade of estrogen receptors or total knockout of estrogen a receptors augments the pressor effects of ANG II. Finally, in females but not in males, central blockade of nitric oxide synthase increases the pressor effects of ANG II. Taken together, these results suggest that sex differences and estrogen and testosterone play important roles in the development of ANG II-induced hypertension |
Disciplines: | Medicina |
Keyword: | Endocrinología, Sistema cardiovascular, Angiotensina, Estrógenos, Receptores químicos, Oxido nítrico, Especies reactivas de oxígeno, Testosterona |
Keyword: | Medicine, Cardiovascular system, Endocrinology, Angiotensin, Estrogens, Chemical receptors, Nitric oxide, Oxygen reactive species, Testosterone |
Full text: | Texto completo (Ver HTML) |