Phenotypic aspects of oral strains of Candida albicans in children with down's syndrome



Document title: Phenotypic aspects of oral strains of Candida albicans in children with down's syndrome
Journal: Brazilian journal of biology
Database: PERIÓDICA
System number: 000275958
ISSN: 1519-6984
Authors: 1
2






Institutions: 1Universidade Federal de Goias, Instituto de Patologia Tropical e Saude Publica, Goiania, Goias. Brasil
2Universidade Federal do Rio Grande do Sul, Instituto de Ciencias Basicas da Saude, Porto Alegre, Rio Grande do Sul. Brasil
Year:
Season: Ago
Volumen: 66
Number: 3
Pages: 939-944
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental
English abstract The aim of this article is to characterize the biological aspects of oral strains of C. albicans in children with Down's syndrome. These yeasts were analyzed as to their macromorphological and enzymatic aspects and were tested as to their in vitro susceptibility to antifungal drugs using broth microdilution to determine the minimum inhibitory concentration (MIC). The morphotyping revealed that all oral C. albicans isolates from children with Down's syndrome promoted the formation of fringes regardless of size, while the control group presented smaller fringes. All oral C. albicans strains produced proteinase, but those with phospholipolytic activity showed greater enzyme capacity in the test group. In vitro susceptibility showed that all oral C. albicans isolates were sensitive to the drugs used
Portuguese abstract O objetivo deste artigo foi caracterizar os aspectos biológicos de cepas de C. albicans orais em crianças com síndrome de Down. Estas leveduras foram analisadas quanto aos seus aspectos macromorfológicos e enzimáticos e foram testadas quanto a sua suscetibilidade in vitro a drogas antifúngicas, usando a microdiluição em caldo para a determinação da concentração inibitória mínima (CIM). A morfotipagem revelou que todos os isolados de C. albicans orais de crianças com síndrome de Down induziram à formação de franjas independente do tamanho, enquanto o grupo controle teve franjas menores. Todas as cepas de C. albicans orais produziram proteinase, mas aquelas com atividade fosfolipidolítica mostraram maior capacidade enzimática no grupo teste. A suscetibilidade in vitro mostrou que todos os isolados de C. albicans orais foram sensíveis a drogas empregadas
Disciplines: Medicina,
Biología
Keyword: Odontología,
Hongos,
Parasitología,
Fenotipos,
Candida albicans,
Síndrome de Down,
Niños
Keyword: Medicine,
Biology,
Dentistry,
Fungi,
Parasitology,
Phenotypes,
Candida albicans,
Down syndrome,
Children
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