| Journal: | Brazilian archives of biology and technology |
| Database: | PERIÓDICA |
| System number: | 000391504 |
| ISSN: | 1516-8913 |
| Authors: | Turkez, Hasan1 Sonmez, Erdal2 Turkez, Ozlem4 Mokhtar, Yousef Ibrahem5 Stefano, Antonio Di6 Turgut, Guven3 |
| Institutions: | 1Erzurum Technical University, Department of Molecular Biology and Genetics, Erzurum. Turquía 2Ataturk University, Graduate School of Natural and Applied Sciences, Erzurum. Turquía 3Ataturk University, Department of Physics, Erzurum. Turquía 4Ataturk University, Department of Biology, Erzurum. Turquía 5Alexandria University, Department of Environmental Studies, Alejandría. Egipto 6Universita "G. D’Annunzio" Chieti-Pescara, Dipartimento di Farmacia, Chieti. Italia |
| Year: | 2014 |
| Season: | Jul-Ago |
| Volumen: | 57 |
| Number: | 4 |
| Pages: | 532-541 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Tungsten (VI) oxide (WO3) nanoparticles (NPs) are used for many industrial purposes in everyday life. However, their effects on human health have not been sufficiently evaluated. Therefore, the present study was designed to investigate the toxicity potentials of various concentrations (0 to 1000 ppm) of WO3 NPs (<100 nm particle size) in cultured primary rat hepatocytes. The results of cell viability assay showed that the higher concentrations of dispersed WO3 NPs (300, 500 and 1000 ppm) caused significant (p<0.05) decreases of cell viability. Also, dose dependent negative alterations were observed in oxidative status and antioxidant capacity levels after the application of WO3 in cultured rat primary hepatocytes. The results of genotoxicity tests revealed that these NPs did not cause significant increases of micronucleated hepatocytes (MNHEPs) but increased 8-oxo-2-deoxyguanosine (8-OH-dG) levels as compared to the control culture |
| Disciplines: | Medicina |
| Keyword: | Ingeniería biomédica, Biomateriales, Nanopartículas, Oxido de tungsteno, Genotoxicidad, Citotoxicidad, Bioensayos, Hepatocitos |
| Keyword: | Medicine, Biomedical engineering, Biomaterials, Nanoparticles, Tungsten oxide, Genotoxicity, Cytotoxicity, Bioassays, Hepatocytes |
| Full text: | Texto completo (Ver HTML) |
