| Journal: | Brazilian archives of biology and technology |
| Database: | PERIÓDICA |
| System number: | 000362760 |
| ISSN: | 1516-8913 |
| Authors: | Turkez, Hasan1 Aydin, Elanur2 |
| Institutions: | 1Erzurum Technical University, Faculty of Science, Erzurum. Turquía 2Ataturk University, Faculty of Science, Erzurum. Turquía |
| Year: | 2013 |
| Season: | May-Jun |
| Volumen: | 56 |
| Number: | 3 |
| Pages: | 405-412 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The aim of this work was to investigate the genetic effects of resveratrol (RSV) at concentrations of 10, 15, 25, 40, 75 and 100 µM and its activities on the genotoxicity induced by the permethrin (PM) (200 µM). After the application of PM and RSV, separately and together, cultured human lymphocytes were assessed by chromosome aberrations (CA) and sister chromatid exchange (SCE) tests. According to results, the frequencies of CA and SCE rates in the peripheral lymphocytes were significantly increased by PM compared with the controls. However, RSV had no genotoxic effect. Furthermore, the findings revealed that PM-induced increases in the mean frequencies of both genotoxic indices were diminished by RSV in a clear dose dependent manner, indicating its protective role towards the cells from PM exerted injury. In conclusion, these effects of RSV should be considered while evaluating the possible use of RSV as a therapeutic agent |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Medicina experimental, Genética, Aberraciones cromosómicas, Mutagenicidad, Permetrina, Protección genética, Resveratrol |
| Keyword: | Medicine, Experimental medicine, Pharmacology, Genetics, Chromosome aberrations, Mutagenicity, Permethrin, Genetic protection, Resveratrol |
| Full text: | Texto completo (Ver HTML) |
