| Journal: | Brazilian archives of biology and technology |
| Database: | PERIÓDICA |
| System number: | 000331994 |
| ISSN: | 1516-8913 |
| Authors: | Bosi, Paula Lima Borges, Gabriel Delfino1 Durigan, Joao Luiz Quagliotti1 Cancelliero, Karina Maria1 Silva, Carlos Alberto da1 |
| Institutions: | 1Universidade Metodista de Piracicaba, Departamento de Fisioterapia, Piracicaba, Sao Paulo. Brasil |
| Year: | 2008 |
| Season: | Mar-Abr |
| Volumen: | 51 |
| Number: | 2 |
| Pages: | 295-301 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The aim of this study was to evaluate the glycogen content (GC) of the rat hind limb muscles submitted to joint immobilization, either associated with metformin treatment (M, 1,4mg.ml-1) or not. In the metformin group, there was a significant increase in the GC (soleus - S 65% , white gastrocnemius - WG 30.5%, red gastrocnemius- RG31.7%, extensor digitorum longus - EDL 44%, tibialis anterior- TA 77.4%). The immobilization significantly reduced the GC (S 31.6%, WG 56.6%, RG 39.1%, ELD 41.7%, TA 45.2%) and weight (S 34.2% and ELD 27%), whereas in the group immobilized with the metformin, there was an increase in the GC of all the muscles (S 177%, WG 290%, RG 172%,ELD 47%, TA 217%), in addition to minimizing the weight loss of S (29.6%) and ELD (27.8%) |
| Portuguese abstract | O objetivo deste estudo foi avaliar o conteúdo de glicogênio (GLI) da musculatura da pata posterior de ratos submetidos à imobilização articular, associado ou não ao tratamento com metformina (MET, 1,4 mg.ml -1) no período de sete dias. No grupo metformina, houve elevação significativa nas RG (65% no sóleo - S, 30.5% no gastrocnêmio branco - GB, 31.7% no gastrocnêmio vermelho - GV , 44% no extensor longo dos dedos - EDL e de 77.4% no tibial anterior - TA ). A imobilização reduziu significativamente as RG (S 31,6%, GB 56,6%, GV 39,1%, ELD 41,7%, TA 45,2%) e peso (S 34,2% e ELD 27%), já no grupo imobilizado com metformina houve o aumento das RG de todos os músculos (S 177%, GB 290%, GV 172%,EDL 47%, TA 217%), além de minimizar a perda de peso do S (29,6%) e ELD (27,8%) |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Plasticidad morfológica, Metformina, Glucógeno, Limitación funcional, Rehabilitación, Músculo esquelético |
| Keyword: | Medicine, Pharmacology, Morphological plasticity, Metformin, Glycogen, Functional limitation, Rehabilitation, Skeletal muscle |
| Full text: | Texto completo (Ver HTML) |
