| Journal: | Brazilian archives of biology and technology |
| Database: | PERIÓDICA |
| System number: | 000387705 |
| ISSN: | 1516-8913 |
| Authors: | Lopes, Edna1 Sousa, Raimundo Vicente de1 Zangeronimo, Marcio Gilberto1 Pereira, Andressa Naira de Jesus1 Coelho, Mariana de Resende1 Ferreira, Matheus Soares da Silva1 Lima, Renato Ribeiro2 Marcondes, Fernanda Klein3 Napimoga, Marcelo Henrique4 Pereira, Luciano Jose1 |
| Institutions: | 1Universidade Federal de Lavras, Departamento de Medicina Veterinaria, Lavras, Minas Gerais. Brasil 2Universidade Federal de Lavras, Departamento de Ciencias Exatas, Lavras, Minas Gerais. Brasil 3Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba, Piracicaba, Sao Paulo. Brasil 4Instituto e Centro de Pesquisas Sao Leopoldo Mandic, Laboratorio de Imunologia e Biologia Molecular, Campinas, Sao Paulo. Brasil |
| Year: | 2015 |
| Season: | May-Jun |
| Volumen: | 58 |
| Number: | 3 |
| Pages: | 406-413 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | This study aimed at evaluating the effect of ractopamine (RAC) on metabolism, zootechnical performance, body composition, and behavior in Wistar rats submitted to acute and chronic restrain stress. The oral dose of 5 mg/kg of RAC was administered in periods of 0, 7, 14, 21, and 28 days. The elevated plus-maze test (EPMT) was used for behavioral assessment. Blood, carcass and viscera characteristics were evaluated. Insulin-dependent glucose transporters (GLUT-4) were semi-quantified by Western Blot in epididymal adipocytes. RAC periods associated with chronic stress increased the GLUT-4 protein expression in adipose tissue in a time-dependent manner (P=0.01), i.e., the longer the RAC addition period, the higher the GLUT-4 concentration in chronically stressed animals (0=1.42; 7=1.19; 14=2.03; 21=1.59; 28=2.35). The stress periods combined with RAC increased the time spent in the opened arms of the maze (Chronic stress: 0=10.6; 7=8.7; 14=5.9; 21=12.3; 28=4.0; Acute stress 0=3.1; 7= 4.7; 14=7.5; 21=0.0; 28=2.8) (P=0.04). Chronic (entries on the closed arms [ECA]=3.60) and acute (ECA=3.80) stress reduced locomotive activity in the maze (P=0.03). The results suggested that stress could negatively affect the possible benefits offered by the RAC, mainly impairing the adipose tissue metabolism and behavior in the animals |
| Disciplines: | Medicina veterinaria y zootecnia |
| Keyword: | Medicina veterinaria, Farmacología, Bioensayos, Ractopamina, Agonistas beta adrenérgicos, Estrés, Ratas, Efectos conductuales, Efectos metabólicos |
| Keyword: | Veterinary medicine and animal husbandry, Veterinary medicine, Pharmacology, Bioassays, Ractopamine, Beta-adrenergic agonists, Stress, Rats, Behavioral effects, Metabolic effects |
| Full text: | Texto completo (Ver HTML) |
