Extracts of red yolk from duck eggs inhibit metastasis of human mammary carcinoma (4T1) cells in mice
Document title: Extracts of red yolk from duck eggs inhibit metastasis of human mammary carcinoma (4T1) cells in mice
Journal: Brazilian archives of biology and technology
Database: PERIÓDICA
System number: 000337636
ISSN: 1516-8913
Authors: 1
1
1
2
1
1
Institutions: 1Renmin Hospital of Wuhan University, Oncology Center, Wuhan, Hubei. China
2Huazhong Agricultural University, College of Food Science and Technology, Wuhan, Hubei. China
Year:
Season: May-Jun
Volumen: 54
Number: 3
Pages: 511-516
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico
English abstract The aim of the present study was to investigate the in vivo anti-metastatic activity of the red pigments of red yolk eggs laid by the ducks dieting on Potamogeton cripus L on the mammary carcinoma (4T1). The pigments were extracted with petroleum ether and acetone (2:1, v/v). BALB/c mice were divided into three groups (n=6), fed with the extracts at 150 mg/kg body weight (BW)/day (DEYE-H) or at 50 mg/kg BW/day (DEYE-L) and identical buffer without the extract (control group). The extracts were administered for 34 days. The treatment significantly inhibited the growth of orthotopical 4T1 tumour (DEYE-H vs control, 1:2; DEYE-L vs control, 2:3) and reduced the metastasis of tumour in the lungs (DEYE-H vs control, 4:7; DEYE-L vs control, 5:7), without statistical difference of body weight among the three groups
Disciplines: Medicina
Keyword: Medicina experimental,
Oncología,
Carotenoides,
Yema de huevo,
Patos,
Metástasis,
Ratones,
Animales de laboratorio,
Carcinoma,
Glándula mamaria
Keyword: Medicine,
Experimental medicine,
Oncology,
Carotenoids,
Egg yolk,
Ducks,
Metastasis,
Mice,
Laboratory animals,
Mammary gland,
Carcinoma
Full text: Texto completo (Ver HTML)