| Journal: | Brazilian archives of biology and technology |
| Database: | PERIÓDICA |
| System number: | 000331984 |
| ISSN: | 1516-8913 |
| Authors: | Austerlitz, Carlos1 Souza, Vivianne Lucia Bormann de1 Campos, Diana Maria Tavares1 Kurachi, Cristina2 Bagnato, Vanderley2 Sibata, Claudio3 |
| Institutions: | 1Comissao Nacional de Energia Nuclear, Centro Regional de Ciencias Nucleares do Nordeste, Recife, Pernambuco. Brasil 2Universidade de Sao Paulo, Sao Carlos, Sao Paulo. Brasil 3East Carolina University, Brody School of Medicine, Greenville, Carolina del Norte. Estados Unidos de América |
| Year: | 2008 |
| Season: | Mar-Abr |
| Volumen: | 51 |
| Number: | 2 |
| Pages: | 271-279 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The vials filled with Fricke solutions were doped with increasing concentrations of Photogem®, used in photodynamic therapy. These vials were then irradiated with low-energy X-rays with doses ranging from 5 to 20 Gy. The conventional Fricke solution was also irradiated with the same doses. The concentration of ferric ions for the Fricke and doped-Fricke irradiated solutions were measured in a spectrophotometer at 220 to 340 nm. The results showed that there was an enhancement in the response of the doped-Fricke solution, which was proportional to the concentration of the photosensitizer. The use of such procedure for studying the radiosensitizing property of photosensitizers based on the production of free radicals is also discussed |
| Portuguese abstract | Tubos de ensaio foram preenchidos com a solução Fricke dopada com Fotogem® em concentrações crescentes; essa hemotoporfirina é utilizada na terapia fotodinâmica. Esses tubos foram irradiados com doses de 5 a 20 Gy. A solução Fricke convencional também foi irradiada com as mesmas doses. As concentrações de íons férricos nas soluções Fricke convencional e dopadas irradiadas foram medidas num espectrofotômetro com comprimento de onda entre 220 e 340 nm. Os resultados mostraram que quando comparado o Fricke convencional com o Fricke dopado irradiado, as amostras dopadas demonstraram um aumento na resposta da dose absorvida que é proporcional a concentração do Photogem® na solução Fricke. Concluímos que esse procedimento pode ser utilizado para propósitos de dosimetria na terapia com radiossensibilizadores |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Oncología, Terapia fotodinámica, Fotosensibilización, Solución de Fricke, Hematoporfirina, Radicales libres |
| Keyword: | Medicine, Oncology, Pharmacology, Photodynamic therapy, Photosensibilization, Fricke solution, Hematoporphyrin, Free radicals |
| Full text: | Texto completo (Ver HTML) |
