| Journal: | Brazilian archives of biology and technology |
| Database: | PERIÓDICA |
| System number: | 000387702 |
| ISSN: | 1516-8913 |
| Authors: | Tharachand, C1 Selvaraj, C. Immanuel1 Abraham, Z |
| Institutions: | 1VIT University, School of Biosciences and Technology, Vellore, Tamil Nadu. India |
| Year: | 2015 |
| Season: | May-Jun |
| Volumen: | 58 |
| Number: | 3 |
| Pages: | 379-386 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | This study aimed to evaluate the in vitro anthelmintic activity and antibacterial activity of the extracts from the leaves and fruits of Garcinia indica (Dupetit-Thouars) Choisy and Garcinia cambogia(Gaertn.) Desr. using the Indian earthworm Pheretima posthuma. Two concentrations (25 and 50 mg/mL) of various extracts such as petroleum ether, chloroform, ethyl acetate, methanol and water were tested. Albendazole at the concentrations of 25 and 50 mg/mL was used as the standard reference. Significant anthelmintic effects of the fruits and leaves of G. cambogia and G. indica (P<0.05) were observed and the results were expressed in terms of paralysis and death time. All the extracts showed the dose dependent paralysis and death of earthworms. Among all the extracts used, methanol extract exhibited the highest activity. G. cambogia leaf extract (50 mg/mL) had 30% faster paralysis effect on earthworms than the standard reference. Furthermore, the antimicrobial activity of the methanol extracts of the fruits and leaves showed significant (P<0.05) activity against Gram-positive and Gram-negative bacteria. At a concentration of 500 µg/mL, G. indica fruit extract presented higher zones of inhibition against Pseudomonas aeruginosa and Staphylococcus aureus. Hence, it could be concluded that the leaves and fruits of G. indica and G. cambogia contained active anthelmintic and antibacterial phytochemicals, which could find their applications in pharmaceuticals |
| Disciplines: | Química, Medicina |
| Keyword: | Química farmacéutica, Angiospermas, Actividad antihelmíntica, Actividad antibacteriana, Concentración inhibitoria mínima, Garcinia cambogia, Garcinia indica, Clusiaceae |
| Keyword: | Chemistry, Medicine, Medicinal chemistry, Angiosperms, Anthelmintic activity, Antibacterial activity, Minimal inhibitory concentration, Garcinia cambogia, Garcinia indica, Clusiaceae |
| Full text: | Texto completo (Ver HTML) |
