| Journal: | Brazilian archives of biology and technology |
| Database: | PERIÓDICA |
| System number: | 000391499 |
| ISSN: | 1516-8913 |
| Authors: | Goncalves, Reggiani Vilela1 Matta, Sergio Luis Pinto da2 Novaes, Romulo Dias3 Leite, Joao Paulo Viana4 Peluzio, Maria do Carmo Gouveia5 Vilela, Emerson Ferreira6 |
| Institutions: | 1Universidade Federal de Vicosa, Departamento de Biologia Animal, Vicosa, Minas Gerais. Brasil 2Universidade Federal de Vicosa, Departamento de Biologia Geral, Vicosa, Minas Gerais. Brasil 3Universidade Federal de Alfenas, Departamento de Biologia celular, Tecidual e do Desenvolvimento, Alfenas, Minas Gerais. Brasil 4Universidade Federal de Vicosa, Departamento de Bioquimica e Biologia Molecular, Vicosa, Minas Gerais. Brasil 5Universidade Federal de Vicosa, Departamento de Nutricao e Saude, Vicosa, Minas Gerais. Brasil 6Universidade Federal de Vicosa, Departamento de Fitotecnia, Vicosa, Minas Gerais. Brasil |
| Year: | 2014 |
| Season: | Jul-Ago |
| Volumen: | 57 |
| Number: | 4 |
| Pages: | 504-513 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The aim of this study was to investigate the effect of bark extract Bathysa cuspidata (BCE) in the reconstitution of hepatic parenchyma and stroma after dysfunction induced by the CCl4. Liver lesions were induced by intraperitoneal administration of CCl4 (1 mL/kg) every 48 h for 12 days. The animals were treated with B. cuspidata extract (BCE) administered by gavage for another 12 days. Forty-nine rats were randomized into seven treatment groups with seven animals receiving CCl4, BCE (200, or 400 mg/kg) and the vehicle DMSO alone, or in different combinations. The extract alone showed no evidence of hepatic toxicity. In general, rats acutely exposed to CCl4 without the treatment with BCE presented high ALT and AST serum levels and high tissue content of lipid hydroperoxides, malondialdehyde, and lipid droplets. BCE administration, especially at 400 mg/kg attenuated significantly all these parameters. Furthermore, the antioxidant activities of the enzymes superoxide dismutase and catalase were significantly increased in the groups receiving this extract. These results showed that the extract of B. cuspidata stem bark stimulated the antioxidant defense system and reduced the morphological and functional liver damage in Wistar rats previously exposed to CCl4 |
| Disciplines: | Química, Medicina |
| Keyword: | Farmacología, Medicina experimental, Plantas medicinales, Daño hepático, Detoxificación, Fitoterapia, Antioxidantes, Bathysa cuspidata, Rubiaceae |
| Keyword: | Chemistry, Medicine, Experimental medicine, Pharmacology, Medicinal plants, Liver injury, Detoxification, Phytotherapy, Antioxidants, Bathysa cuspidata, Rubiaceae |
| Full text: | Texto completo (Ver HTML) |
