| Journal: | Boletín médico del Hospital Infantil de México |
| Database: | PERIÓDICA |
| System number: | 000347113 |
| ISSN: | 1665-1146 |
| Authors: | Margoles, Lindsay1 Río, Carlos del2 Franco Paredes, Carlos3 |
| Institutions: | 1Emory University, Department of Medicine, Atlanta, Georgia. Estados Unidos de América 2Emory University, Rollins School of Public Health, Atlanta, Georgia. Estados Unidos de América 3Hospital Infantil de México "Federico Gómez", México, Distrito Federal. México |
| Year: | 2011 |
| Season: | Mar-Abr |
| Volumen: | 68 |
| Number: | 2 |
| Pages: | 120-126 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Leprosy or Hansen's disease is a chronic mycobacterial infectious disease caused by Mycobacterium leprae and affects mainly peripheral nerves and skin as well as upper respiratory mucosae. This infection is a conjoined bacteriological and immunological disease. Target cells of infection are macrophages, histiocytes in the skin, and the nonmyelinating and myelinating Schwann cells in the peripheral nerves leading to axonal dysfunction and demyelination leading to functional impairment and deformity. Leprosy reactions represent the most important determinant of nerve impairment if untreated and unrecognized. Control of leprosy transmission remains a challenge despite substantial improvements through the use of multidrug therapy in many settings. Most importantly, although many patients have been microbiologically cured through the efforts of the World Health Organization, many are left with significant disability that has recently been estimated to be ~20% of those treated (~15 million individuals) in the last decades. Further efforts are needed to elucidate the epidemiology and risk factors for disability among those with multibacillary forms |
| Disciplines: | Medicina |
| Keyword: | Dermatología, Inmunología, Enfermedades tropicales, Lepra, Farmacoterapia, Inmunosupresión, Rifampicina, Clofazimina, Dapsona, Mycobacterium leprae |
| Keyword: | Medicine, Dermatology, Immunology, Tropical diseases, Leprosy, Drug therapy, Immunosuppression, Rifampicin, Clofazimine, Dapsone, Mycobacterium leprae |
| Full text: | Texto completo (Ver HTML) |
