The relationship between neurocysticercosis and epilepsy: an endless debate



Document title: The relationship between neurocysticercosis and epilepsy: an endless debate
Journal: Arquivos de neuro-psiquiatria
Database: PERIÓDICA
System number: 000372426
ISSN: 0004-282X
Authors: 1
2
Institutions: 1Universidad de Cuenca, Facultad de Medicina, Cuenca, Azuay. Ecuador
2City University of New York, School of Public Health, Nueva York. Estados Unidos de América
Year:
Season: May
Volumen: 72
Number: 5
Pages: 383-390
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Descriptivo
English abstract Neurocysticercosis (NC), or cerebral infection with Taenia solium, is an important public health problem worldwide. Among the neurological sequelae of NC, seizures have been described as the most common symptom. Acute symptomatic seizures often result from degeneration of a viable cyst; however, not all of these patients with acute or provoked seizures will develop epilepsy (i.e., recurrent unprovoked seizures). Because of the high prevalence of epilepsy and NC, a causal, as well as incidental relationship between the two may exist. The epileptogenicity of calcified cysts as well as the potential association between NC and hippocampal sclerosis necessitates future research. Antihelminthic treatment of NC results in disappearance of viable cysts in about one-third of patients with parenchymal disease, but a reduction in seizure recurrence has not been demonstrated in randomized controlled trials. Prevention is critical to reduce the burden of seizure and epilepsy related to NC
Portuguese abstract A neurocisticercose (NC) ou infecção cerebral pela Taenia solium é importante problema de saúde pública em todo o mundo. Entre as sequelas neurológicas da NC, as crises convulsivas têm sido descritas como os sintomas mais frequentes. Crises convulsivas sintomáticas agudas resultam, muitas vezes, da degeneração de cistos viáveis; entretanto, nem todos os pacientes com NC e crises agudas ou provocadas desenvolvem epilepsia (i.e., crises recorrentes não provocadas). Pode haver uma relação entre epilepsia e NC, causal ou incidental, devido à alta prevalência de ambas. O potencial epileptogênico dos cistos calcificados assim como a possível associação entre NC e esclerose hipocampal ainda necessitam de futuras pesquisas. O tratamento anti-helmíntico da NC resulta no desaparecimento de cistos viáveis em cerca de 1/3 dos pacientes com a doença parenquimatosa, mas não foi demonstrada redução nas taxas de recorrência das crises convulsivas em estudos randomizados controlados. A prevenção é crítica para reduzir o contingente de crises convulsivas e epilepsia relacionadas à NC
Disciplines: Medicina
Keyword: Diagnóstico,
Microbiología,
Neurología,
Neurocisticercosis,
Cisticercosis,
Taenia solium,
Convulsiones,
Epilepsia,
Etiología
Keyword: Medicine,
Diagnosis,
Microbiology,
Neurology,
Neurocysticercosis,
Cysticercosis,
Taenia solium,
Seizures,
Epilepsy,
Etiology
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