Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients
Document title: Serum levels of adiponectin, CCL3/MIP-1α, and CCL5/RANTES discriminate migraine from tension-type headache patients
Journal: Arquivos de neuro-psiquiatria
Database: PERIÓDICA
System number: 000401967
ISSN: 0004-282X
Authors: 1
1
2
2
2
3
1
Institutions: 1Universidade Federal de Minas Gerais, Programa de Neurociencias, Belo Horizonte, Minas Gerais. Brasil
2Senne Liquor Diagnostico, Sao Paulo. Brasil
3Hospital Israelita Albert Einstein, Laboratorio de Patologia Clinica, Sao Paulo. Brasil
Year:
Season: Ago
Volumen: 74
Number: 8
Pages: 626-631
Country: Brasil
Language: Inglés
Document type: Estadística o encuesta
Approach: Analítico
English abstract Objectives Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache. Methods This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded. Results We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain. Conclusions This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches
Portuguese abstract Objetivos Moléculas inflamatórias e fatores neurotróficos estão implicados na modulação dolorosa, contudo, seu papel nas cefaleias primárias não é claro. O objetivo do presente estudo foi comparar níveis de biomarcadores séricos na migrânea e cefaleia do tipo tensional. Métodos Este foi um estudo transversal, no qual foram avaliados níveis de adiponectina, quimiocinas e fatores neurotróficos em pacientes com migrânea e cefaleia do tipo tensional. Sintomas depressivos e ansiosos, o impacto e a frequência da cefaleia e alodínea foram registrados. Resultados Foram incluídos 68 pacientes com migrânea e 48 pacientes com cefaleia do tipo tensional. A alodínia cutânea (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), e adiponectina (p = 0.017) foram maiores na migrânea, independentemente de sintomas depressivos e ansiosos, frequência e impacto da cefaleia. Conclusões Níveis de CCL3/MIP-1α, CCL5/RANTES e adiponectina foram maiores na migrânea do que na cefaleia do tipo tensional, sugerindo papeis distintos destas moléculas na fisiopatologia destas duas cefaleias primárias
Disciplines: Medicina
Keyword: Neurología,
Genética,
Cefalea tensional,
Migraña,
Adiponectina,
Quimiocinas,
Factores neurotróficos,
Biomarcadores
Keyword: Medicine,
Neurology,
Genetics,
Tensional headache,
Migraine,
Adiponectin,
Chemokines,
Neurotrophic factors,
Biomarkers
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