Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder



Document title: Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder
Journal: Arquivos de neuro-psiquiatria
Database: PERIÓDICA
System number: 000371281
ISSN: 0004-282X
Authors: 1
2
1
1
1
1
Institutions: 1Zhengzhou University, First Affiliated Hospital, Zhengzhou, Henan. China
2Henan Provincial People's Hospital, Zhengzhou, Henan. China
Year:
Season: Ene
Volumen: 72
Number: 1
Pages: 44-48
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Aplicado
English abstract Objective: To explore the relationship between regional cerebral blood flow (CBF) and cognitive function in obsessive-compulsive disorder (OCD). Method: Single-photon emission computed tomography (SPECT) was performed for 139 OCD patients and 139 controls, and the radioactivity rate (RAR) was calculated. Cognitive function was assessed by the Wisconsin Card Sorting Test (WCST). Results: The RARs of the prefrontal, anterior temporal, and right occipital lobes were higher in patients than controls. For the WCST, correct and classification numbers were significantly lower, and errors and persistent errors were significantly higher in OCD patients. Right prefrontal lobe RAR was negatively correlated with correct numbers, right anterior temporal lobe RAR was positively correlated with errors, and the RARs of the right prefrontal lobe and left thalamus were positively correlated with persistent errors. Conclusion: OCD patients showed higher CBF in the prefrontal and anterior temporal lobes, suggesting that these areas may be related with cognitive impairment
Portuguese abstract Objetivo: Estudar a relação entre a perfusão sanguínea regional cerebral e as funções cognitivas em pacientes com transtorno obsessivo compulsivo (TOC). Método: Foram estudados 139 pacientes com TOC e 139 controles. As imagens do fluxo sanguíneo cerebral foram feitas por single photon emission computed tomography e o radioactivity rate (RAR) foi calculado usando como referência a radioatividade do córtex cerebelar. As funções cognitivas foram avaliadas através do Wisconsin Card Sorting Test (WCST). Resultados: O RAR do lobo pré-frontal, do lobo temporal anterior e do lobo occipital direito foram mais elevados nos pacientes do que nos controles (P<0.05). Quanto ao WCST, os escores de números corretos (P<0.01) e de classificação (P<0.05) foram menores no grupo TOC do que nos controles; entretanto, os escores de erros e de erros persistentes nos controles foram mais elevados do que nos pacientes (P<0.01). O RAR do lobo pré-frontal direito estava relacionado de modo negativo com os números corretos; o RAR do lobo temporal anterior apresentava correlação positiva com os erros; o RAR do lobo pré-frontal direito e do tálamo esquerdo apresentavam correlação positiva com erros persistentes. Conclusão: Pacientes com TOC apresentaram perfusão sanguínea cerebral mais intensa no lobo pré-frontal e no lobo temporal anterior. O lobo pré-frontal direito, o lobo temporal e o tálamo esquerdo podem estar relacionados com alterações cognitivas
Disciplines: Medicina
Keyword: Diagnóstico,
Neurología,
Trastorno obsesivo-compulsivo,
Flujo sanguíneo cerebral,
Función cognitiva,
Evaluación cognitiva
Keyword: Medicine,
Diagnosis,
Neurology,
Obsessive-compulsive disorder,
Cerebral blood flow,
Cognitive functions,
Cognitive assessment
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