Refractory epilepsy in children with brain tumors. The urgency of neurosurgery



Document title: Refractory epilepsy in children with brain tumors. The urgency of neurosurgery
Journal: Arquivos de neuro-psiquiatria
Database: PERIÓDICA
System number: 000403724
ISSN: 0004-282X
Authors: 1
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Institutions: 1Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil
Year:
Season: Dic
Volumen: 74
Number: 12
Pages: 1008-1013
Country: Brasil
Language: Inglés
Document type: Estadística o encuesta
Approach: Analítico
English abstract In order to verify indications for surgery, 27 patients with refractory epileptic seizures and brain tumor, aged up to 19 years at the time of surgery, were studied between 1996 and 2013 and followed up for at least one year. The mean interval between the onset of seizures and the diagnosis of the tumor was 3.6 years, and from diagnosis to the surgery, 18 months. The location of the tumor was in the temporal lobe in 16, with ganglioglioma and dysembryoplastic neuroepithelial tumors being the most frequent. Among the patients, 92.5% and 90.4% were seizure-free in the first and fifth year after surgery, respectively. Twelve of 16 children were successful in becoming drug-free, with complete withdrawal by 3.2 years. Surgery proved to be potentially curative and safe in these cases, suggesting that the tumor diagnosis and surgery cannot be postponed
Portuguese abstract A fim de verificar os aspectos da indicação cirúrgica, vinte e sete pacientes com epilepsia refratária secundária a tumor cerebral, com idade de até 19 anos na cirurgia, operados entre 1996 e 2013 e seguidos por pelo menos um ano, foram estudados. O intervalo médio entre o início das crises e o diagnóstico do tumor foi de 3,6 anos, e deste para a cirurgia, 18 meses. A localização do tumor foi lobo temporal em 16, sendo ganglioglioma e DNET os tipos mais frequentes. Entre os pacientes, 92,5% e 90,4% estavam livres de crises no primeiro e no quinto ano após a cirurgia, respectivamente. Doze de 16 crianças obtiveram sucesso na retirada de drogas, com a média de tempo de 3,2 anos após o procedimento. A cirurgia provou ser potencialmente curativa e segura nestes casos, o que sugere que perante o diagnóstico de tumor esta não pode ser adiada
Disciplines: Medicina
Keyword: Cirugía,
Diagnóstico,
Neurología,
Neoplasias,
Cerebro,
Epilepsia refractaria,
Neurocirugía,
Convulsiones,
Evolución
Keyword: Medicine,
Diagnosis,
Neurology,
Surgery,
Neoplasias,
Brain,
Refractory epilepsy,
Neurosurgery,
Seizures,
Evolution
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