Neurological symptoms and signs in HTLV-1 patients with overactive bladder syndrome



Document title: Neurological symptoms and signs in HTLV-1 patients with overactive bladder syndrome
Journal: Arquivos de neuro-psiquiatria
Database: PERIÓDICA
System number: 000345711
ISSN: 0004-282X
Authors: 1
1
1
1
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2
Institutions: 1Universidade Federal da Bahia, Hospital Universitario Professor Edgard Santos, Salvador, Bahia. Brasil
2Weill Cornell Medical College, Nueva York. Estados Unidos de América
Year:
Season: Abr
Volumen: 70
Number: 4
Pages: 252-256
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract OBJECTIVE: To compare neurological symptoms and signs in HTLV-1 asymptomatic carriers and HTLV-1 patients with overactive bladder (OB) syndrome. METHODS: We studied 102 HTLV-1 positive individuals without HAM/TSP (HTLV-1 associated myelopathy/tropical spastic paraparesis) divided into two groups according to the presence or absence of OB syndrome. Clinical interview, neurological exam and proviral load was performed in all patients. RESULTS AND CONCLUSIONS: Individuals with OB were more commonly female (84.3 vs. 60.8% of asymptomatics, p=0.01). The prevalence of neurological complaints was higher in OB group, especially hand or foot numbness and arm or leg weakness. There was no difference between the groups in neurological strength and reflexes. Weakness complaint remained strongly associated with OB in multivariate logistic regression analysis adjusting for sex and age [adjusted odds ratio and 95%CI 3.59 (1.45-8.88) in arms and 6.68 (2.63-16.93) in legs]. Proviral load was also different between the two groups with higher level on OB individuals
Portuguese abstract OBJETIVO: Comparar sintomas e sinais neurológicos em pacientes portadores do HTLV-1 assintomáticos e com síndrome de bexiga hiperativa (BH). MÉTODOS: Foram estudados 102 indivíduos com HTLV-1 sem HAM/TSP (mielopatia associada ao HTLV-I/paraparesia espástica tropical), divididos em dois grupos segundo a presença ou ausência de BH. Foram realizados em todos os pacientes entrevista clínica, exame neurológico e carga proviral. RESULTADOS E CONCLUSÕES: Indivíduos com BH foram na maioria do sexo feminino (84,3 vs. 60,8% dos assintomáticos, p=0,01). A prevalência de queixas neurológicas foi maior no grupo BH, especialmente dormências e fraqueza em extremidades. Não houve diferença entre os grupos em relação a achados do exame neurológico. Fraqueza subjetiva permaneceu fortemente associada com BH na regressão logística multivariada ajustada para sexo e idade [OR e IC95% 3,59 (1,45-8,88) nos braços e 6,68 (2,63-16,93) nas pernas]. A carga proviral foi também diferente entre os dois grupos com nível maior em indivíduos com BH
Disciplines: Medicina
Keyword: Microbiología,
Nefrología,
Neurología,
HTLV-1,
Paraparesia espástica tropical,
Mielitis,
Vejiga neurogénica
Keyword: Medicine,
Microbiology,
Nephrology,
Neurology,
HTLV-1,
Tropical spastic paraparesis,
Myelitis,
Neurogenic bladder
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