| Journal: | Arquivos de neuro-psiquiatria |
| Database: | PERIÓDICA |
| System number: | 000420955 |
| ISSN: | 0004-282X |
| Authors: | Rodríguez Violante, Mayela1 Ospina García, Natalia1 Dávila Avila, Ned Merari1 Cruz Fino, Diego1 Cruz Landero, Alejandra de la1 Cervantes Arriaga, Amin1 |
| Institutions: | 1Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Laboratorio Clínico de Enfermedades Neurodegenerativas, Ciudad de México. México |
| Year: | 2018 |
| Season: | Ago |
| Volumen: | 76 |
| Number: | 8 |
| Pages: | 517-521 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | The wearing-off phenomenon is common in patients with Parkinson's disease. Motor and non-motor symptoms can fluctuate in relation to the “on/off” periods. Objective: To assess the impact of motor and non-motor wearing-off on activities of daily living and quality of life of patients with PD. Methods: A cross-sectional study was carried out. All patients were evaluated using the Movement Disorders Society Unified Parkinson's Disease Rating Scale. Wearing-off was assessed using the Wearing-Off Questionnaire-19, and quality of life was assessed using the Parkinson's Disease Questionnaire-8. Results: A total of 271 patients were included; 73.4% had wearing-off; 46.8% had both motor and non-motor fluctuations. Patients with both motor and non-motor wearing-off had a worst quality of life compared with those with only motor fluctuations (p = 0.047). Conclusions: Motor and non-motor fluctuations have an impact on activities of daily living and quality of life. Non-motor wearing-off may have a higher impact |
| Portuguese abstract | O fenômeno de encurtamento do fim de dose é comum em pacientes com doença de Parkinson. Tanto os sintomas motores quanto os não motores podem flutuar em relação aos períodos de “on/off”. Objetivo: Avaliar o impacto das flutuações motoras e não-motoras nas atividades da vida diária e qualidade de vida em pacientes com doença de Parkinson. Métodos: Um estudo transversal foi realizado. Todos os sujeitos foram avaliados utilizando a escala unificada para a doença de Parkinson da Sociedade de Distúrbios do Movimento. O encurtamento do fim de dose foi avaliado através do questionário WOQ-19 e a qualidade de vida foi avaliada através do PDQ-8. Resultados: Um total de 271 pacientes foram incluídos, 73,4% tiveram deterioração de fim de dose. A maioria dos pacientes tiveram tanto flutuações motoras quanto não-motoras (46,8%). Os pacientes com ambos os tipos de flutuaçoes motoras e nao-motoras tiveram pior qualidade |
| Disciplines: | Medicina |
| Keyword: | Neurología, Enfermedad de Parkinson, Actividad motora, Deterioro, Actividades cotidianas, Calidad de vida |
| Keyword: | Neurology, Parkinson disease, Motor activity, Wearing-off, Daily activity, Quality of life |
| Full text: | Texto completo (Ver HTML) |
