Monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of pulmonary function evaluation in amyotrophic lateral sclerosis
Document title: Monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of pulmonary function evaluation in amyotrophic lateral sclerosis
Journal: Arquivos de neuro-psiquiatria
Database: PERIÓDICA
System number: 000361048
ISSN: 0004-282X
Authors: 1
1
1
2
3
3
Institutions: 1Universidade Federal do Rio Grande do Norte, Departamento de Fisioterapia, Natal, Rio Grande do Norte. Brasil
2Universidade Federal do Rio Grande do Norte, Hospital Universitario Onofre Lopes, Natal, Rio Grande do Norte. Brasil
3Universidade Federal de Pernambuco, Departamento de Fisioterapia, Recife, Pernambuco. Brasil
Year:
Season: Mar
Volumen: 71
Number: 3
Pages: 146-152
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Aplicado, analítico
English abstract Objective It was study the relationship between respiratory muscle strength and forced vital capacity (FVC) in patients with amyotrophic lateral sclerosis (ALS) versus healthy subjects. Methods Pulmonary function and respiratory muscle strength [maximal inspiratory (PImax), maximal expiratory (PEmax) and sniff nasal inspiratory pressure (SNIP)] were assessed in patients with ALS and healthy subjects, matched using cutoffs established in the literature for impaired pulmonary function and respiratory muscle weakness. Results Twenty-eight ALS patients and 28 healthy subjects were studied. We found sensitivity and specificity for PImax, PEmax and SNIP of 75/58%, 81/67% and 75/67%. The Receiver Operating Characteristic curve (ROC curve) indicated that the variables PImax, PEmax and SNIP can identify differences in respiratory muscle strength between ALS and healthy individuals at 0.89, 0.9 and 0.82, respectively. A positive correlation was recorded between FVC (%) versus SNIP, PImax and PEmax. Conclusion In ALS, monitoring respiratory muscle strength assists in early diagnosis of respiratory dysfunction as opposed to the isolated use of FVC
Portuguese abstract Objetivo Estudar a relação entre a força dos músculos respiratórios e a capacidade vital forçada (CVF) em pacientes com esclerose lateral amiotrófica (ELA) e sujeitos saudáveis. Métodos Avaliamos a função pulmonar e a força dos músculos respiratórios [pressão inspiratória (PImax), pressão expiratória (PEmax) e pressão inspiratória nasal de sniff (SNIP)] utilizando pontos de corte estabelecidos na literatura para diagnóstico de fraqueza muscular respiratória. Resultados Foram estudados 28 pacientes com ELA e 28 sujeitos saudáveis. Encontramos sensibilidade e especificidade para PImax, PEmax e SNIP de 75/58%, 81/67% e 75/67%. A curva ROC (Receiver Operating Characteristic) indicou que as variáveis PImax, PEmax e SNIP podem identificar diferenças na força dos músculos respiratórios em pacientes com ELA versus sujeitos saudáveis em 0,89, 0,9 e 0,82 respectivamente. Foi encontrada uma correlação positiva entre CVF (%) e SNIP, PImax e PEmax. Conclusão Em pacientes com ELA, o monitoramento da força muscular respiratória auxilia no diagnóstico precoce da disfunção em detrimento do uso da CVF isolada
Disciplines: Medicina
Keyword: Diagnóstico,
Neumología,
Neurología,
Esclerosis lateral amiotrófica,
Función respiratoria,
Músculos respiratorios,
Fuerza muscular,
Función pulmonar
Keyword: Medicine,
Diagnosis,
Neurology,
Pneumology,
Amyotrophic lateral sclerosis,
Respiratory function,
Respiratory muscles,
Muscular strength,
Pulmonary function
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