Depression increases in patients with Parkinson?s disease according to the increasing severity of the cognitive impairment
Document title: Depression increases in patients with Parkinson?s disease according to the increasing severity of the cognitive impairment
Journal: Arquivos de neuro-psiquiatria
Database: PERIÓDICA
System number: 000377531
ISSN: 0004-282X
Authors: 1
2
3
4
2
2
Institutions: 1Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil
2Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Sao Paulo. Brasil
3Hospital Israelita Albert Einstein, Instituto Israelita de Ensino e Pesquisa, Sao Paulo. Brasil
4Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México, Distrito Federal. México
Year:
Season: Jun
Volumen: 72
Number: 6
Pages: 426-429
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Objective : To test the hypothesis that severity of cognitive impairment modifies the association between depression and Parkinson’s disease (PD). Method : One-phase population-based door-to-door surveys. This is a secondary analysis of 1,451 people aged 65 years and older with cognitive impairment living in defined catchment areas. Depression was estimated according to ICD-10, self-reported PD, disability according to WHODAS-II and cognitive status according to the CSI-D. Results : The mean age of the sample was 79.3 years old and most (69%) were women. Of the total sample, 16.1% had depression and it was significantly higher among participants with PD. There was an increase on the ORs of the association between depression and PD with decreased scores in the cognitive test (Adjusted OR from 0.98 to 8.04). Conclusion : The association between depression and PD increases with the severity of the cognitive impairment
Portuguese abstract Objetivo : Testar a hipótese que a gravidade do prejuízo cognitivo modifica a associação entre depressão e doença de Parkinson (DP). Método : Estudo populacional através da análise secundária de 1.451 pessoas com idade maior ou igual a 65 anos com prejuízo cognitivo que residiam em áreas de abrangência definidas. A depressão foi estimada de acordo com a CID-10, auto-relato de DP, incapacidade conforme a WHODAS-II e nível cognitvo de acordo com a CSI-D. Resultado : A média de idade foi 79,3 anos, predominaram as mulheres (69%). Do total de indivíduos, 16,1% tinham depressão, significantemente maior entre os participantes com DP. Houve aumento gradativo na OR relativa à associação entre depressão e DP com a diminuição do escore no teste cognitivo (OR ajustado variou de 0,98 a 8,04). Conclusão : A associação entre depressão e DP parece aumentar com a gravidade do prejuízo cognitivo
Disciplines: Medicina
Keyword: Neurología,
Psiquiatría,
Enfermedad de Parkinson,
Deterioro cognitivo,
Depresión
Keyword: Medicine,
Neurology,
Psychiatry,
Parkinson disease,
Cognitive impairment,
Depression
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