Current perspectives in stem cell therapy for spinal cord repair in humans: a review of work from the past 10 years



Document title: Current perspectives in stem cell therapy for spinal cord repair in humans: a review of work from the past 10 years
Journal: Arquivos de neuro-psiquiatria
Database: PERIÓDICA
System number: 000377552
ISSN: 0004-282X
Authors: 1
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Institutions: 1Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo. Brasil
2Eberhard-Karls University, Department of Neurosurgery, Tuebingen. Alemania
Year:
Season: Jun
Volumen: 72
Number: 6
Pages: 451-456
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Spinal cord injury (SCI) and amyotrophic laterals sclerosis (ALS) are devastating neurological conditions that affect individuals worldwide, significantly reducing quality of life, both for patients and their relatives. Objective : The present review aims to summarize the multiple restorative approaches being developed for spinal cord repair, the use of different stem cell types and the current knowledge regarding stem cell therapy. Method : Review of the literature from the past 10 years of human studies using stem cell transplantation as the main therapy, with or without adjuvant therapies. Conclusion : The current review offers an overview of the state of the art regarding spinal cord restoration, and serves as a starting point for future studies
Portuguese abstract Lesão medular (LM) e esclerose lateral amiotrófica (ELA) são condições devastadoras que acometem pessoas em todo o mundo, reduzindo a qualidade de vida tanto de pacientes como de entes queridos. Objetivo : A atual revisão tem como alvo as múltiplas abordagens restauradoras para a regeneração medular, o uso de diferentes tipos celulares e o atual conhecimento a cerca da terapia com células tronco. Método : Revisão de literatura dos últimos 10 anos usando transplantes de células tronco como estratégia principal, com ou sem terapia adjuvante, em humanos. Conclusão : A presente revisão oferece uma visão geral acerca da restauração medular e serve de ponto de partida para estudos futuros
Disciplines: Medicina
Keyword: Neurología,
Terapéutica,
Lesión medular,
Esclerosis lateral amiotrófica,
Terapia celular,
Células troncales
Keyword: Medicine,
Neurology,
Therapeutics,
Spinal cord injury,
Amyotrophic lateral sclerosis,
Cell therapy,
Stem cells
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