| Journal: | Arquivo brasileiro de medicina veterinaria e zootecnia |
| Database: | PERIÓDICA |
| System number: | 000287468 |
| ISSN: | 0102-0935 |
| Authors: | Alves, C.M1 Vasconcelos, A.C Martins, A.S Puerto, H.L. del Santos, F.G.A Nunes, J.E.S Campos, P.P Moro, L |
| Institutions: | 1Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil |
| Year: | 2006 |
| Season: | Ago |
| Volumen: | 58 |
| Number: | 4 |
| Pages: | 472-479 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | The thymic morphometry analysis was used for determining apoptosis and atrophy of the thymus of eight puppies inoculated with canine distemper virus (CDV). Three healthy dogs were used as negative controls. Sections, 5µm thick, were stained by HE and Shorr, and the latter were evaluated by morphometry. CDV nucleoprotein was detected by immunohistochemistry. Morphometric results confirmed lymphoid hypotrophy in CDV inoculated dog thymuses, more stroma, less parenchyma and higher apoptotic index/field than negative control (not inoculated) puppies. Apoptosis plays a role in the mechanism of thymus atrophy that develops in canine distemper |
| Portuguese abstract | Determinaram-se a apoptose e a atrofia no timo de oito cães novos, inoculados experimentalmente com o vírus de cinomose. Três cães saudáveis foram usados como controle negativo. Secções coradas pelo Shorr foram avaliadas por morfometria. A nucleoproteína viral foi detectada por imunoistoquímica. Os resultados morfométricos confirmaram a hipotrofia e mostraram que o timo dos cães inoculados tinha mais estroma, menos parênquima e maior índice apoptótico/campo que o dos animais-controle. Pode-se concluir que a apoptose desempenha importante papel no mecanismo de hipotrofia tímica que se desenvolve na cinomose |
| Disciplines: | Medicina veterinaria y zootecnia, Biología |
| Keyword: | Medicina veterinaria, Inmunología, Virus, Timo, Perros, Inmunosupresión, Moquillo, Apoptosis |
| Keyword: | Veterinary medicine and animal husbandry, Biology, Veterinary medicine, Immunology, Virus, Thymus, Dogs, Distemper, Apoptosis, Immunosuppression |
| Full text: | Texto completo (Ver HTML) |
