| Journal: | Archivos venezolanos de farmacología y terapéutica |
| Database: | PERIÓDICA |
| System number: | 000393038 |
| ISSN: | 0798-0264 |
| Authors: | Manfredi, Roberto1 Calza, Leonardo1 |
| Institutions: | 1Universita di Bologna, Hospital Santa Orsola, Bolonia, Emilia Romaña. Italia |
| Year: | 2008 |
| Volumen: | 27 |
| Number: | 2 |
| Pages: | 92-104 |
| Country: | Venezuela |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, descriptivo |
| English abstract | Multiresistant Gram-positive cocci, including Staphylococcus aureus, the group of coagulase-negative staphylococci, Enterococcus faecalis and Enterococcus faecium, as well as Streptococcus pneumoniae and other streptococci, represent emerging pathogens. This issue is especially concerning in the setting of immunocompromised, hospitalized patients, in particular when surgery, invasive procedures, or prosthetic implants are carried out, patients are admitted in intensive care units, or underlying chronic disorders and immunodeficiency are of concern, and broad-spectrum antibiotics are widely used in the environment; moreover, a community spread of resistant Gram-positive cocci has been recognized during recent years. The spectrum of antimicrobials available for an effective management of these relevant infections is significantly threatened by the emerging of methicillin-resistant and more recently glycopeptide-resistant strains. The streptogramine association represented by quinupristin/dalfopristin, the oxazolidinone derivative linezolid, and the recently licensed daptomycin and tigecycline, together with a number of glycopeptides, fluoroquinolones, cephalosporins, and other experimental compounds, represent an effective response. It is due to the innovative mechanisms of action of these compounds, their maintained or enhanced activity against multiresistant pathogens, their effective pharmacokinetic/pharmacodynamic properties, their frequent possibility of synergistic activity with other compounds effective against Gram-positive pathogens, and a diffuse potential for a safe and easy administration, also to compromised patients. The main problems related to the epidemiology of multiresistant gram-positive infection, the potential clinical indications of all recently available compounds compared with the standard of care of treatment of resistant Gram-positive infections, and updated data on efficacy and tolerability |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Terapéutica y rehabilitación, Bacterias, Bacterias Gram positivas, Antimicrobianos, Oxazolidinonas, Estreptograminas, Resistencia bacteriana, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Streptococcus pneumoniae |
| Keyword: | Medicine, Pharmacology, Therapeutics and rehabilitation, Bacteria, Gram positive bacteria, Antimicrobial agents, Oxazolidinones, Streptogramins, Bacterial resistance, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Streptococcus pneumoniae |
| Full text: | Texto completo (Ver HTML) |
