Post stroke depression: clinics, etiopathogenesis and therapeutics

Document title: Post stroke depression: clinics, etiopathogenesis and therapeutics
Journal: Archives of clinical psychiatry
System number: 000409857
Authors: 1
Institutions: 1Universidade Federal de Minas Gerais, Escola de Medicina, Belo Horizonte, Minas Gerais. Brasil
2Universidade de Sao Paulo, Hospital Universitario, Sao Paulo. Brasil
Season: Ene-Feb
Volumen: 42
Number: 1
Pages: 18-24
Country: Brasil
Language: Inglés
Document type: Revisión bibliográfica
Approach: Analítico
English abstract Stroke is a major cause of morbidity and mortality worldwide. Neuropsychiatric disorders are often associated with stroke and, among them, depression is the most prevalent. Post-stroke Depression (PSD) is related to disability, failure in returning to work, impairment in interpersonal functioning and mortality. Its etiopathogenesis is still uncertain, as well as its treatment. In Brazil, there are few data on the impact of PSD. Objective This work is dedicated to conduct a comprehensive review of the concept of PSD, its pathophysiology, morbidity and treatment. Methods PubMed, Medline and Lilacs searches of relevant terms yielded 3,265 papers in the last 10 years. We selected original studies and reviews that addressed the aspects mentioned above. Results We present the history of the notion of PSD and describe its epidemiology, looking to highlight Brazilian studies. Diagnostic criteria and clinical presentation were detailed, with emphasis on cognitive aspects. The four main pathophysiological theories proposed to PSD are presented and we discuss the various treatment strategies, involving psychopharmacologic options, brain stimulation techniques and psychotherapy. Discussion This work provides comprehensive information on PSD, of great utility for clinical practice and research in this topic
Disciplines: Medicina
Keyword: Diagnóstico,
Terapéutica y rehabilitación,
Accidentes cerebrovasculares,
Deterioro cognitivo
Keyword: Medicine,
Therapeutics and rehabilitation,
Cognitive impairment
Full text: Texto completo (Ver HTML)