| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000418044 |
| ISSN: | 1665-2681 |
| Authors: | Sales, Ibrahim1 Dzierba, Amy L2 Smithburger, Pamela L1 Rowe, Deanna3 Kane-Gill, Sandra L1 |
| Institutions: | 1University of Pittsburgh, Medical Center, Pittsburgh, Pensilvania. Estados Unidos de América 2Presbyterian Hospital, Department of Pharmacy, Nueva York. Estados Unidos de América 3University of Pittsburgh, School of Pharmacy, Pittsburgh, Pensilvania. Estados Unidos de América |
| Year: | 2013 |
| Season: | Feb |
| Volumen: | 12 |
| Pages: | 6-10 |
| Country: | México |
| Language: | Inglés |
| Document type: | Revisión bibliográfica |
| Approach: | Analítico |
| English abstract | The purpose of this review was to evaluate the effectiveness of acetylcysteine in the treatment of acute liver failure not related to acetaminophen. A search of MEDLINE April 2003 through May 2012 using the PubMed database was conducted using the keywords acetylcysteine and non-acetaminophen-induced acute liver failure or acetylcysteine and liver failure. All human case reports, case series, and research articles that discussed the use of acetylcysteine for non-acetaminophen induced liver failure were evaluated. A total of 263 articles were identified during this broad search with 11 articles included for review in this article; eight case reports, two retrospective trials, and one prospective, randomized, double-blind multicenter study. In conclusion, the data suggest marginal benefit of IV acetylcysteine in NAI-ALF with coma grades I-II; however, the routine use of acetylcysteine cannot be recommended. It may be considered in non-transplant centers while awaiting referral or when transplantation is not an option. Further studies are necessary to determine optimal dosing, duration, and criteria for patient selection |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Farmacología, Insuficiencia hepática aguda, Acetilcisteína, Efectos adversos, Antídotos |
| Keyword: | Gastroenterology, Pharmacology, Acute liver failure, Acetylcysteine, Adverse effects, Antidotes |
| Full text: | Texto completo (Ver PDF) |
