| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000411828 |
| ISSN: | 1665-2681 |
| Authors: | Teschke, Rolf1 Zhang, Li2 Long, Hongzhu3 Schwarzenboeck, Alexander1 Schmidt Taenzer, Wolfgang1 Genthner, Alexander1 Wolff, Albrecht4 Frenzel, Christian5 Schulze, Johannes1 Eickhoff, Axel1 |
| Institutions: | 1Goethe University, Medical Faculty, Frankfurt, Hessen. Alemania 2China Food and Drug Administration, Center for Drug Reevaluation, Beijing. China 3Beijing University of Chinese Medicine, Dongfang Hospital, Beijing. China 4Friedrich Schiller University Jena, Division of Gastroenterology, Hepatology and Infectious Diseases, Jena, Thuringen. Alemania 5University Medical Center Hamburg-Eppendorf, Department of Medicine I, Hamburgo. Alemania |
| Year: | 2015 |
| Season: | Ene-Feb |
| Volumen: | 14 |
| Number: | 1 |
| Pages: | 7-19 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Traditional Chinese Medicine (TCM) with its focus on herbal use became popular worldwide. Treatment was perceived as safe, with neglect of rare adverse reactions including liver injury. To compile worldwide cases of liver injury by herbal TCM, we undertook a selective literature search in the PubMed database and searched for the items Traditional Chinese Medicine, TCM, Traditional Asian Medicine, and Traditional Oriental Medicine, also combined with the terms herbal hepatotoxicity or herb induced liver injury. The search focused primarily on English-language case reports, case series, and clinical reviews. We identified reported hepatotoxicity cases in 77 relevant publications with 57 different herbs and herbal mixtures of TCM, which were further analyzed for causality by the Council for International Organizations of Medical Sciences (CIOMS) scale, positive reexposure test results, or both. Causality was established for 28/57 different herbs or herbal mixtures, Bai Xian Pi, Bo He, Ci Wu Jia, Chuan Lian Zi, Da Huang, Gan Cao, Ge Gen, Ho Shou Wu, Huang Qin, Hwang Geun Cho, Ji Gu Cao, Ji Xue Cao, Jin Bu Huan, Jue Ming Zi, Jiguja, Kudzu, Ling Yang Qing Fei Keli, Lu Cha, Rhen Shen, Ma Huang, Shou Wu Pian, Shan Chi, Shen Min, Syo Saiko To, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, and Zhen Chu Cao. In conclusion, this compilation of liver injury cases establishes causality for 28/57 different TCM herbs and herbal mixtures, aiding diagnosis for physicians who care for patients with liver disease possibly related to herbal TCM |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Gastroenterología, Plantas medicinales, Hepatotoxicidad |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Medicinal plants, Hepatotoxicity |
| Full text: | Texto completo (Ver PDF) |
