| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000418422 |
| ISSN: | 1665-2681 |
| Authors: | Levstik, Mark1 Wong, Philip2 Greanya, Erica D3 Yoshida, Eric M4 |
| Institutions: | 1London Health Sciences Centre, The Multi-Organ Transplant Program, London, Ontario. Canadá 2McGill University, Division of Gastroenterology, Montreal, Quebec. Canadá 3Vancouver Coastal Health, Pharmaceutical Sciences, Vancouver, Columbia Británica. Canadá 4University of British Columbia, Division of Gastroenterology, Vancouver, Columbia Británica. Canadá |
| Year: | 2011 |
| Season: | Oct-Dic |
| Volumen: | 10 |
| Number: | 4 |
| Pages: | 441-444 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Hepatitis B virus (HBV) related liver transplant (LT) recipients face a high risk of HBV reinfection in the absence of continuous post-operative HBV prophylaxis. Combination HBV prophylaxis with hepatitis B immune globulin (HBIg) and nucleos(t)ide anti-viral agents prevents HBV recurrence in 90 to 100% of patients who undergo transplantation for hepatitis B and is considered the standard of care in Canada. Post liver transplant HBV prophylaxis protocols vary with regard to the dosing, duration and routes of HBIg administration. All Canadian transplant centres managing liver transplant patients were surveyed as to their HBV transplant protocols. Results. Results of the survey showed that the majority of the Canadian transplant centres use an oral antiviral in combination with long term or indefinite HBIg for prevention of HBV recurrence post liver transplantation. Studies were done to test new protocols using lower HBIg doses given intramuscularly or subcutaneously alone or in combination with antiviral agents. Conclusion. Long term HBIg administration post transplantation in combination with antiviral agents is an integral part of Canadian HBV related liver transplant protocol |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Farmacología, Trasplante de hígado, Hepatitis B, Inmunoglobulinas |
| Keyword: | Gastroenterology, Pharmacology, Liver transplantation, Hepatitis B, Immunoglobulins |
| Full text: | Texto completo (Ver PDF) |
