| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000407191 |
| ISSN: | 1665-2681 |
| Authors: | Simental Mendía, Luis E1 Simental Mendía, Esteban1 Rodríguez Hernández, Heriberto2 Rodríguez Morán, Martha1 Guerrero Romero, Fernando1 |
| Institutions: | 1Instituto Mexicano del Seguro Social, Unidad de Investigación Biomédica, Durango. México 2Universidad Juárez del Estado de Durango, Facultad de Medicina y Nutrición, Durango. México |
| Year: | 2016 |
| Season: | Sep-Oct |
| Volumen: | 15 |
| Number: | 5 |
| Pages: | 715-720 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Introduction and aim. Given that early identification of non-alcoholic fatty liver disease (NAFLD) is an important issue for primary prevention of hepatic disease, the objectives of this study were to evaluate the efficacy of the product of triglyceride and glucose levels (TyG) for screening simple steatosis and non-alcoholic steatohepatitis (NASH) in asymptomatic women, and to compare its efficacy vs. other biomarkers for recognizing NAFLD. Material and methods. Material and methods. Material and methods. Asymptomatic women aged 20 to 65 years were enrolled into a cross-sectional study. The optimal values of TyG, for screening simple steatosis and NASH were established on a Receiver Operating Characteristic scatter plot; the sensitivity, specificity, and likelihood ratios of TyG index were estimated versus liver biopsy. According sensitivity and specificity, the efficacy of TyG was compared versus the well-known clinical biomarkers for recognizing NAFLD. Results. Results. A Results. total of 50 asymptomatic women were enrolled. The best cutoff point of TyG for screening simple steatosis was 4.58 (sensitivity 0.94, specificity 0.69); in addition, the best cutoff point of TyG index for screening NASH was 4.59 (sensitivity 0.87, specificity 0.69). The positive and negative likelihood ratios were 3.03 and 0.08 for simple steatosis, and 2.80 and 0.18 for NASH. As compared versus SteatoTest, NashTest, Fatty liver index, and Algorithm, the TyG showed to be the best test for screening. Conclusions. Conclusions. TyG Conclusions. has high sensitivity and low negative likelihood ratio; as compared with other clinical biomarkers, the TyG showed to be the best test for screening simple steatosis and NASH |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Gastroenterología, Esteatohepatitis no alcohólica, Prevención primaria, Biomarcadores, Triglicéridos, Glucosa, Hígado graso no alcohólico |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Non-alcoholic steatohepatitis, Primary prevention, Biomarkers, Triglycerides, Glucose, Non alcoholic fatty liver |
| Full text: | Texto completo (Ver PDF) |
