| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000411741 |
| ISSN: | 1665-2681 |
| Authors: | Yu, Kangkang1 Shi, Guangfeng1 Li, Ning1 |
| Institutions: | 1Fudan University, Huashan Hospital, Shanghai. China |
| Year: | 2015 |
| Season: | Jul-Ago |
| Volumen: | 14 |
| Number: | 4 |
| Pages: | 450-456 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | MicroRNAs represent a class of non-coding RNA molecules that negatively regulate gene expression either by repressing translation or by inducing degradation of messenger RNA. Studies have shown that, as regulators of gene expression, microRNAs are widely involved in various human diseases, including hepatitis B virus-related liver diseases. By modulating hepatitis B virus replication, regulating extracellular matrix formation, as well as silencing tumor suppressor genes, these small molecules are implicated in the development of chronic hepatitis, liver fibrosis/cirrhosis, and hepatocellular carcinoma caused by hepatitis B virus infection. In addition, current researches indicated a potential role of microRNA as diagnostic markers and therapeutic targets. In conclusion, microRNAs are promising tools in the diagnosis and treatment of hepatitis B virus -related liver diseases |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Virus de la hepatitis B, Fisiopatología, MicroARNs, Expresión génica, Hepatitis crónica, Carcinoma hepatocelular |
| Keyword: | Medicine, Gastroenterology, Hepatitis B virus, Physiopathology, MicroRNAs, Gene expression, Chronic hepatitis, Hepatocellular carcinoma |
| Full text: | Texto completo (Ver PDF) |
