| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000417651 |
| ISSN: | 1665-2681 |
| Authors: | Gabrielli, Mauricio1 Moisan, Fabrizio1 Vidal, Marcela1 Duarte, Ignacio1 Jiménez, Macarena1 Izquierdo, Guillermo1 Domínguez, Pilar1 Méndez, Javier2 Soza, Alejandro1 Benítez, Carlos1 Pérez, Rosa1 Arrese, Marco1 Guerra, Juan1 Jarufe, Nicolás1 Martínez, Jorge1 |
| Institutions: | 1Pontificia Universidad Católica de Chile, Facultad de Medicina, Santiago de Chile. Chile 2Corporación del Trasplante, Santiago de Chile. Chile |
| Year: | 2012 |
| Season: | Nov-Dic |
| Volumen: | 11 |
| Number: | 6 |
| Pages: | 891-898 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, analítico |
| English abstract | Steatotic livers have been associated with greater risk of allograft dysfunction in liver transplantation. Our aim was to determinate the prevalence of steatosis in grafts from deceased donors in Chile and to assess the utility of a protocol-bench biopsy as an outcome predictor of steatotic grafts in our transplant program. Material and methods. We prospectively performed protocol-bench graft biopsies from March 2004 to January 2009. Biopsies were analyzed and classified by two independent pathologists. Steatosis severity was graded as normal from absent to < 6%; grade 1: 6-33%; grade 2: > 33-66% and grade 3: > 66%. Results. We analyzed 58 liver grafts from deceased donors. Twenty-nine grafts (50%) were steatotic; 9 of them (16%) with grade 3. Donor age (p < 0.001) and BMI over 25 kg/m2 (p = 0.012) were significantly associated with the presence of steatosis. There were two primary non-functions (PNF); both in a grade 3 steatotic graft. The 3-year overall survival was lower among recipients with macrovesicular steatotic graft (57%) than recipients with microvesicular (85%) or non-steatotic grafts (95%) (p = 0.026). Conclusion. Macrovesicular steatosis was associated with a poor outcome in this series. A protocol bench-biopsy would be useful to identify these grafts |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Diagnóstico, Hígado graso, Esteatosis, Trasplantes, Hígado, Lesiones, Donadores |
| Keyword: | Gastroenterology, Diagnosis, Fatty liver, Steatosis, Transplantation, Liver, Lesions, Donors |
| Full text: | Texto completo (Ver PDF) |
