| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000416611 |
| ISSN: | 1665-2681 |
| Authors: | Almajhdi, Fahad N1 Al-Ahdal, Mohammed2 Abdo, Ayman A3 Sanai, Faisal M4 Al-Anazi, Mashael2 Khalaf, Nisreen2 Viswan, Nisha A2 Al-Ashgar, Hamad5 Al-Kahtani, Khalid5 Al-Humaidan, Hind2 Al-Swayeh, Riham2 Hussain, Zahid6 Alarifi, Saud6 Al-Okail, Majid6 Al-Qahtani, Ahmed2 |
| Institutions: | 1King Saud University, College of Science, Riyadh. Arabia Saudita 2King Faisal Specialist Hospital & Research Center, Research Center, Riyadh. Arabia Saudita 3King Saud University, College of Medicine, Riyadh. Arabia Saudita 4King Saud University, Liver Disease Research Center, Riyadh. Arabia Saudita 5King Faisal Specialist Hospital & Research Center, Department of Medicine, Riyadh. Arabia Saudita 6King Saud University, Center of Excellence in Biotechnology Research, Riyadh. Arabia Saudita |
| Year: | 2013 |
| Season: | Mar-Abr |
| Volumen: | 12 |
| Number: | 2 |
| Pages: | 220-227 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico |
| English abstract | This study aims to investigate whether the SNPs of CXCR1 gene, could predict the likelihood of viral persistence and/or disease progression. Material and methods. We investigated the association of two different SNPs (rs2234671, and rs142978743) in 598 normal healthy controls and 662 HBV patients from a Saudi ethnic population. The HBV patients were categorized into inactive carriers (n = 428), active carriers (n = 162), cirrhosis (n = 54) and Cirrhosis-HCC (n = 18) sub-groups. Genetic variants in CXCR1 were determined by polymerase chain reaction (PCR)-based DNA direct sequencing. Results. The frequency of the risk allele ‘C’ for the SNP, rs2234671 was found to be insignificant when the patient group was compared to the uninfected control group, however, a significant distribution of the allele ‘C’ of rs2234671 was observed among active HBV carriers + cirrhosis + cirrhosis - HCC vs. inactive HBV carriers with an OR = 1.631 (95% C.I. 1.016-2.616) and p = 0.032. However, no significant association was observed for rs142978743 when the distribution of risk allele was analyzed among the different patient groups (i.e. inactive carriers, active carriers, cirrhosis and HCC). Furthermore, the most common haplotype, Haplo-1 (AG), was found to have an insignificant frequency distribution between HBV cases and controls, while the same haplotype was found to be significantly distributed when active carriers + cirrhosis + cirrhosis - HCC patients were compared to inactive HBV carriers with a frequency of 0.938 and p = 0.0315. Haplo-2 (AC) was also found to be significantly associated with a frequency of 0.058 and p = 0.0163. Conclusion. The CXCR1 polymorphism, rs2234671 was found to be associated with chronic HBV infection and may play a role in disease activity |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Genética, Virus de la hepatitis B, CXCR1, Genes, Polimorfismos de nucleótido único (SNPs), Variaciones, Haplotipos, Arabia Saudita |
| Keyword: | Gastroenterology, Genetics, Hepatitis B virus, CXCR1, Genes, Single nucleotide polymorphism (SNPs), Variations, Haplotypes, Saudi Arabia |
| Full text: | Texto completo (Ver PDF) |
