| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000390991 |
| ISSN: | 1665-2681 |
| Authors: | Gutiérrez Vidal, Roxana1 Vega Badillo, Joel1 Reyes Fermín, Laura M1 Hernández Pérez, Hugo A1 Sánchez Muñoz, Fausto2 López Alvarez, Guadalupe S3 Larrieta Carrasco, Elena4 Fernández Silva, Itzel5 Méndez Sánchez, Nahum6 tovar, Armando R7 Villamil Ramírez, Hugo1 Mejía Domínguez, Ana M8 Villarreal Molina, Teresa9 Hernández Pando, Rogelio10 Campos Pérez, Francisco5 Aguilar Salinas, Carlos A11 Canizales Quinteros, Samuel1 |
| Institutions: | 1Universidad Nacional Autónoma de México, Facultad de Química, México, Distrito Federal. México 2Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Inmunología, México, Distrito Federal. México 3Instituto Politécnico Nacional, Centro de Investigación y de Estudios Avanzados, México, Distrito Federal. México 4Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Gastroenterología, México, Distrito Federal. México 5Hospital General Dr. Rubén Leñero, Clinica Integrada de Cirugía para la Obesidad y Enfermedades Metabólicas, México, Distrito Federal. México 6Fundación Clínica Médica Sur, Unidad de Hígado, México, Distrito Federal. México 7Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Fisiología de la Nutrición, México, Distrito Federal. México 8Instituto Nacional de Cardiología Ignacio Chávez, Banco de Sangre, México, Distrito Federal. México 9Instituto Nacional de Medicina Genómica, Laboratorio de Enfermedades Cardiovasculares, México, Distrito Federal. México 10Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Patología, México, Distrito Federal. México 11Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Endocrinología y Metabolismo, México, Distrito Federal. México |
| Year: | 2015 |
| Season: | Sep-Oct |
| Volumen: | 14 |
| Number: | 5 |
| Pages: | 666-674 |
| Country: | México |
| Language: | Inglés |
| Document type: | Estadística o encuesta |
| Approach: | Analítico |
| English abstract | Secreted frizzled-related protein 5 (SFRP5) was recently described as a new adipokine protective for hepatic steatosis and other obesity-related complications in the mouse model. To date, SFRP5 expression in non-alcoholic fatty liver disease (NAFLD) has not been fully assessed in humans. We measured circulating SFRP5 levels and its expression in liver and adipose tissue, and evaluated its association with NAFLD in morbidly obese women. Material and methods. Fifty-four morbidly obese women undergoing bariatric surgery were included in the study. Liver biopsies were used for histology and hepatic triglyceride content quantification. Circulating SFRP5 levels were measured through enzyme-linked immunoabsorbent assay, and SFRP5 expression was performed in hepatic and adipose tissue (subcutaneous and visceral). Results. Although circulating SFRP5 levels showed a tendency to decrease with NAFLD progression, no significant differences were observed among non-alcoholic steatosis, steatohepatitis, and control subjects. Hepatic SFRP5 expression showed a negative correlation with hepatic triglyceride content (r = -0.349, P = 0.016 for mRNA and r = -0.291, P = 0.040 for SRFP5 protein) and ALT serum levels (r = -0.437, P = 0.001 for SRFP5 protein). In addition, hepatic SFRP5 protein levels were significantly lower in NASH than in control subjects (P = 0.006). Conclusion. This is the first study reporting an association of hepatic SFRP5 expression with NAFLD in humans |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Metabolismo y nutrición, Bioquímica, Expresión hepática, Obesidad mórbida, Adipocinas, Hígado graso no alcohólico, Secreted frizzled-related protein 5 |
| Keyword: | Medicine, Gastroenterology, Metabolism and nutrition, Biochemistry, Secreted frizzled-related protein 5, Hepatic expression, Morbid obesity, Adipokines, Non alcoholic fatty liver |
| Full text: | Texto completo (Ver PDF) |
