Serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver disease
Document title: Serum level of soluble vascular cell adhesion molecule in patients with hepatocellular carcinoma and its association with severity of liver disease
Journal: Annals of hepatology
Database: PERIÓDICA
System number: 000416618
ISSN: 1665-2681
Authors: 1
2
3
2
2
4
2
2
1
2
2
Institutions: 1Hospital Universitario del Sureste, unidad de Gastroenterology Unit, Arganda del Rey, Madrid. España
2Hospital General Universitario Gregorio Marañón, Unidad de Hígado y Ciberehd, Madrid. España
3Hospital Universitario Infanta Sofía, Unidad de Gastroenterología, San Sebastián de los Reyes, Madrid. España
4Hospital del Tajo, Unidad de Gastroenterología, Aranjuez, Madrid. España
Year:
Season: Mar-Abr
Volumen: 12
Number: 2
Pages: 236-247
Country: México
Language: Inglés
Document type: Estadística o encuesta
Approach: Analítico
English abstract VCAM-1 (soluble vascular cell adhesion molecule-1) plays a role in liver angiogenesis. Hepatocellular carcinoma (HCC) has important angiogenic activity, so expression of VCAM-1 may be pathogenic. Aim. To assess the association between serum VCAM-1 (sVCAM-1) levels and features of tumour and liver disease in patients with and without HCC, and to study the influence of HCC treatment on sVCAM-1 levels. Material and methods. Concentrations in peripheral (sVCAM-1-P) and hepatic (sVCAM-1-H) veins were analysed using ELISA in 134 consecutive patients with chronic liver disease between May 2004 and February 2006, who underwent a splanchnic haemodynamic study. Of these patients, 58 had HCC. Results. sVCAM-1-P and sVCAM-1-H were well correlated in both groups. No association was found between sVCAM-1-H and tumour features. No differences were observed in sVCAM-1-H between HCC and non-HCC cirrhotic patients. There was a significant linear association between Child-Pugh stage and sVCAM-1-H in HCC-patients (Child-Pugh A [2,485 ± 1,294 ng/mL] vs. Child-Pugh B [3,408 ± 1,338 ng/mL] vs. Child-Pugh C [4,096 ± 862 ng/ mL]; p = 0.007). Seven non-cirrhotic HCC patients had a significantly lower sVCAM-1-H than cirrhotic HCC patients. Treatment of HCC leads to an increase in sVCAM-1-H levels although this was not associated with the necrosis response to treatment. Conclusions. sVCAM-1 levels are more closely associated with the severity of underlying liver disease than with the presence of HCC. sVCAM-1 levels are not associated with tumour features or invasiveness; therefore, sVCAM-1 does not seem to play an important role in the angiogenic processes of HCC
Disciplines: Medicina
Keyword: Gastroenterología,
Terapéutica y rehabilitación,
Cirrosis,
Acido hialurónico,
Moléculas de adhesión,
Angiogénesis,
Carcinoma hepatocelular
Keyword: Gastroenterology,
Therapeutics and rehabilitation,
Cirrhosis,
Hyaluronic acid,
Adhesion molecules,
Angiogenesis,
Hepatocellular carcinoma
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