| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000419205 |
| ISSN: | 1665-2681 |
| Authors: | Chuan Li1 Tian-Fu Wen1 Lu-Nan Yan1 Bo Li1 Jia-Ying Yang1 Ming-Qing Xu1 Wen-Tao Wang1 Yong-Gang Wei1 |
| Institutions: | 1Sichuan University, West China Hospital, Sichuan. Puerto Rico |
| Year: | 2012 |
| Season: | Jul-Ago |
| Volumen: | 11 |
| Number: | 4 |
| Pages: | 471-477 |
| Country: | México |
| Language: | Inglés |
| Document type: | Estadística o encuesta |
| Approach: | Analítico |
| English abstract | Living donor liver transplantation (LDLT) for patients with high model for end-stage liver disease (MELD) scores is controversial due to its poor outcome. However, there is little information regarding which factor would negatively impact the outcome of patients with high MELD scores. The aim of this study was to identify factors associated with the in-hospital mortality of patients with high MELD scores after LDLT. Material and methods. All patients with an MELD scores ≥ 20 who received LDLT from 2005 to 2011 were recruited for the present study. Pre- and intra-operative variables were retrospectively and statistically analyzed. Results. A total of 61 patients were included in the current study. The overall 3-month survival rate was 82% for patients with high MELD scores. Preoperative renal dysfunction, hyponatremia, starting albumin level < 2.8 g/dL, preoperative renal replacement for severe renal failure, anhepatic period > 100 minutes and intraoperative red blood cell (RBC) transfusion ≥ 10 units were identified as potential risk factors by univariate analysis. However, only hyponatremia, preoperative dialysis and massive RBC transfusion were independent risk factors in a multivariate analysis. The 3-month survival rates of patients with two or more independent risk factors and patients with none or one risk factor were 91 and 25%, respectively. A significant difference was observed (P < 0.001). Conclusion. Hyponatremia, preoperative dialysis and massive RBC transfusion were related to poor outcome for sicker patients. Patients with two or more of the above-mentioned risk factors and high MELD scores may exhibit extremely poor short-term survival |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Cirugía, Diagnóstico, Trasplantes, Hígado, Mortalidad, Factores de riesgo, Donadores vivos |
| Keyword: | Gastroenterology, Surgery, Diagnosis, Transplantation, Liver, Mortality, Risk factors, Living donors |
| Full text: | Texto completo (Ver PDF) |
