| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000390994 |
| ISSN: | 1665-2681 |
| Authors: | Barreto, Adller G.C1 Daher, Elizabeth F1 Silva-Junior, Geraldo B2 Garcia, Jose Huygens P3 Magalhaes, Clarissa B.A1 Lima, Jose Milton C1 Viana, Cyntia F.G3 Pereira, Eanes D.B1 |
| Institutions: | 1Universidade Federal do Ceara, Faculdade de Medicina, Fortaleza, Ceara. Brasil 2Universidade de Fortaleza, Faculdade de Medicina, Fortaleza, Ceara. Brasil 3Universidade Federal do Ceara, Hospital Universitario Walter Cantidio, Fortaleza, Ceara. Brasil |
| Year: | 2015 |
| Season: | Sep-Oct |
| Volumen: | 14 |
| Number: | 5 |
| Pages: | 688-694 |
| Country: | México |
| Language: | Inglés |
| Document type: | Estadística o encuesta |
| Approach: | Analítico |
| English abstract | The aim of this study is to evaluate the risk factors for acute kidney injury (AKI) and 30-day mortality after liver transplantation. Material and methods. This is a retrospective cohort of consecutive adults undergoing orthotopic liver transplantation (OLT) at a referral hospital in Brazil, from January 2013 to January 2014. Risk factors for AKI and death were investigated. Results. A total 134 patients were included, with median age of 56 years. AKI was found in 46.7% of patients in the first 72 h after OLT. Risk factors for AKI were: viral hepatitis (OR 2.9, 95% CI = 1.2-7), warm ischemia time (OR 1.1, 95% CI = 1.01-1.2) and serum lactate (OR 1.3, 95%CI = 1.02-1.89). The length of intensive care unit (ICU) stay was longer in AKI group: 4 (3-7) days vs. 3 (2-4) days (p = 0.001), as well as overall hospitalization stay: 16 (9-26) days vs. 10 (8- 14) days (p = 0.001). The 30-day mortality was 15%. AKI was an independent risk factor for mortality (OR 4.3, 95% CI = 1.3-14.6). MELD-Na ≥ 22 was a predictor for hemodialysis need (OR 8.4, 95%CI = 1.5-46.5). Chronic kidney disease (CKD) was found in 36 patients (56.2% of AKI patients). Conclusions. Viral hepatitis, longer warm ischemia time and high levels of serum lactate are risk factors for AKI after OLT. AKI is a risk factor for death and can lead to CKD in a high percentage of patients after OLT. A high MELD-Na score is a predictor for hemodialysis need |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Nefrología, Salud pública, Insuficiencia renal aguda (IRA), Trasplantes, Hígado, Factores de riesgo, Mortalidad, Donación de órganos |
| Keyword: | Medicine, Gastroenterology, Nephrology, Public health, Acute renal failure (ARF), Transplantation, Liver, Mortality, Risk factors, Organ donation |
| Full text: | Texto completo (Ver PDF) |
