Pulmonary complications of treatment with pegylated interferon for hepatitis C infection-Two case reports
Document title: Pulmonary complications of treatment with pegylated interferon for hepatitis C infection-Two case reports
Journal: Annals of hepatology
Database: PERIÓDICA
System number: 000415691
ISSN: 1665-2681
Authors: 1
1
1
1
Institutions: 1Bradford Teaching Hospitals NHS Foundation Trust, Bradford Royal Infirmary, Bradford, West Yorkshire. Reino Unido
Year:
Season: Jul-Ago
Volumen: 12
Number: 4
Pages: 461-465
Country: México
Language: Inglés
Document type: Artículo
Approach: Caso clínico
English abstract Pegylated interferon (Peg-IFN) in combination with ribavirin is the standard of care in the treatment of chronic hepatitis C (HCV). Peg-IFN is known to have a number of side effects but severe respiratory complications are uncommon. We report two cases, one of Peg-IFN induced interstitial pneumonitis (IP) and the other of bronchiolitis obliterans organising pneumonia (BOOP) in patients with chronic hepatitis C infection. In general, respiratory complications of Peg-IFN are mild and resolve with withdrawal of Peg-IFN. However, as illustrated in our first case fatal interstitial pneumonitis can occur. We present a review of the available literature on Peg-IFN induced lung toxicity. In conclusion, pulmonary toxicity with Peg-IFN is rare but fatality can occur. We highlight the importance of maintaining a high index of suspicion for early diagnosis and prompt treatment, which includes withdrawal of Peg-IFN and consideration of corticosteroid treatment
Disciplines: Medicina
Keyword: Farmacología,
Gastroenterología,
Hepatitis C,
Interferón pegilado,
Efectos adversos,
Neumonitis intersticial,
Bronquiolitis obliterante
Keyword: Medicine,
Gastroenterology,
Pharmacology,
Hepatitis C,
Pegylated interferon,
Adverse effects,
Interstitial pneumonitis,
Bronchiolitis obliterans
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