Protective role of standardized Feronia limonia stem bark methanolic extract against carbon tetrachloride induced hepatotoxicity
Document title: Protective role of standardized Feronia limonia stem bark methanolic extract against carbon tetrachloride induced hepatotoxicity
Journal: Annals of hepatology
Database: PERIÓDICA
System number: 000417664
ISSN: 1665-2681
Authors: 1
2
3
3
3
1
Institutions: 1Herbal Drug Technology Laboratory, Gujarat. India
2The M.S. University of Baroda, Faculty of Technology and Engineering, Gujarat. India
3The M.S. University of Baroda, Faculty of Science, Gujarat, Gujarat. India
Year:
Season: Nov-Dic
Volumen: 11
Number: 6
Pages: 935-943
Country: México
Language: Inglés
Document type: Artículo
Approach: Experimental, analítico
English abstract Objective. This study evaluates hepatoprotective potential of Feronia limonia stem bark (FSB) extracts and fractions using experimental models. Materials and methods. Activity levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and cell viability were evaluated in HepG2 cells treated with carbon tetrachloride (CCl4) in presence or absence of FL extracts or fractions. Also, plasma markers of hepatic damage, hepatic antioxidants, lipid peroxidation and histopathological alterations were assessed in rats treated with CCl4 alone or in combination with 200 or 400 mg/kg bodyweight (BW) of FSB-7 or 25 mg/kg BW of silymarin. Results. In vitro co-supplementation of FSB extracts or fractions recorded varying degree of hepatoprotective potentials. Also, pre-supplementation of FSB methanolic extract (FSB-7) followed by CCl4 treatment significantly prevented hepatic damage and depletion of cellular antioxidants. Also, CCl4+ FSB-7 group showed minimal distortion in the histoarchitecture of liver and results were comparable to that of CCl4+ silymarin treated rats. Conclusion. This inventory is the first scientific report on hepatoprotective potential of FSB methanolic extract
Disciplines: Medicina
Keyword: Gastroenterología,
Bioquímica,
Feronia limonia,
Hepatoprotección,
Antioxidantes,
Bioensayos,
Histopatología,
Marmesina,
Silimarina
Keyword: Gastroenterology,
Biochemistry,
Feronia limonia,
Hepatoprotection,
Antioxidants,
Bioassays,
Histopathology,
Marmesin,
Silymarin
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