| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415009 |
| ISSN: | 1665-2681 |
| Authors: | Nelia Hernández1 Bessone, Fernando2 Sánchez, Adriana1 Pace, María di1 Brahm, Javier3 Zapata, Rodrigo4 Chirino, Ruby A5 Dávalos, Milagros6 Méndez Sánchez, Nahum7 Arrese, Marco8 Schinoni, María9 Lucena, M. Isabel10 Andrade, Raúl J10 |
| Institutions: | 1Universidad de la República, Hospital de Clínicas, Montevideo. Uruguay 2Hospital Provincial del Centenario, Servicio de Gastroenterología y Hepatología, Rosario, Santa Fe. Argentina 3Universidad de Chile, Hospital Clínico, Santiago de Chile. Chile 4Hospital Salvador, Departamento de Gastroenterología, Santiago de Chile. Chile 5Hospital Angeles del Pedregal, México, Distrito Federal. México 6Hospital Nacional Edgardo Rebagliati, Departamento del Aparato Digestivo, Lima. Perú 7Fundación Clínica Médica Sur, Unidad de Hepatología, México, Distrito Federal. México 8Universidad Católica de Chile, Facultad de Medicina Pontificia, Santiago de Chile. Chile 9Universidade Federal da Bahia, Hospital Universitario Edgard Santos, Salvador, Bahia. Brasil 10Universidad de Málaga, Hospital Universitario Virgen de la Victoria, Málaga, Santander. España |
| Year: | 2014 |
| Season: | Mar-Abr |
| Volumen: | 13 |
| Number: | 2 |
| Pages: | 231-239 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Drug-induced liver injury (DILI) remains a major problem for drug development and represents a challenging diagnosis for clinicians. The absence of specific biomarkers for diagnosing DILI precludes the availability of reliable data on the epidemiology of the disease. In this study we aimed to describe the features of idiosyncratic hepatotoxicity reports in Latin American countries. Material and methods. A literature search was performed using the online version of MEDLINE, EMBASE, Scopus, Google Scholar and specific data bases from Latin America (LA) (Scielo, Lilacs) to identify any case report or case series of published DILI from 1996 to 2012. From 1996 to 2012, a total of 176 patients with DILI were published in LA, involving 53 suspicious drugs. The median age in the adult population of these patients was 55 years (17-82) with prevalence of women (67%). Among main therapeutic classes, the rank order was led by non-steroidal anti-inflammatory (61 cases) and systemic antibacterial drugs (37 cases). Nimesulide was the individual drug responsible for the highest number of cases (53), followed by cyproterone acetate (18), nitrofurantoin (17), antituberculous drugs (13) and flutamide (12). Thirty two percent of published cases evolved to acute liver failure (ALF), and half of the subjects required liver transplantation or eventually died. Conclusions. This study represents the first structured attempt to assess the spectrum of DILI profile in LA. The establishment of a Latin American registry to collect prospective DILI cases using a standardized protocol will advance our knowledge about idiosyncratic DILI in this region |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Gastroenterología, Antiinflamatorios no esteroideos, Antibacterianos, Nimesulida, Acetato de ciproterona, Nitrofurantoina, Flutamida, Hepatotoxicidad, Lesión hepática inducida por fármacos |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Non steroidal antinflammatory drugs, Antibacterial agents, Nimesulide, Cyproterone acetate, Nitrofurantoin, Flutamide, Hepatotoxicity, Drug induced liver injury |
| Full text: | Texto completo (Ver PDF) |
