| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000416610 |
| ISSN: | 1665-2681 |
| Authors: | Keyvani, Hossein1 Agah, Shahram2 Kabir, Ali3 Alavian, Seyed Moayed4 |
| Institutions: | 1Tehran University of Medical Sciences, Department of Virology, Teherán. Irán 2Tehran University of Medical Sciences, Gastrointestinal and Liver Diseases Research Center, Teherán. Irán 3Shahid Beheshti University of Medical Sciences, Faculty of Public Health, Teherán. Irán 4Baqiyatallah University of Medical Sciences, Research Center for Gastroenterology and Liver Dieases, Teherán. Irán |
| Year: | 2013 |
| Season: | Mar-Abr |
| Volumen: | 12 |
| Number: | 2 |
| Pages: | 213-219 |
| Country: | México |
| Language: | Inglés |
| Document type: | Estadística o encuesta |
| Approach: | Analítico |
| English abstract | Recent studies have demonstrated that prevention of hepatitis B virus (HBV) transmission remains a challenge in hemodialysis (HD) patients. The aim of this study is to explore factors which increase the possibility of occult HBV (OHB) infection in patients under HD in Iran. Material and methods. Among 2188 cases who spent an average of 60.2 ± 61.1 months under HD, we selected 103 cases with isolated antihepatitis B virus core antibody (anti-HBc) and 231 controls without any HBV, hepatitis D virus (HDV) and hepatitis C virus (HCV) serologic markers. Socio-demographic data, past medical history, and clinical signs and symptoms were assessed. Results. The frequency of checking hepatitis B serologic markers was 15.3%. The rate of OHB infection in HD patients who were monitored for their HBV markers was 4.9%. Cases with isolated anti-HBc had significantly higher percentage of positive HBV DNA [odds ratio: OR (95% confidence interval: 95% CI) = 12.1 (1.4-105)], visual disturbances [OR (95% CI) = 1.8 (1.1-3.03)], history of diabetes mellitus [OR (95% CI) = 2.1 (1.3-3.5)], higher age, higher age when dialysis started and were mostly married, illiterate, disabled and retired. Diabetes mellitus was the only independent predictor of HBV DNA status in cases with isolated anti-HBc. Conclusion. In our region, OHB infection is prevalent among hemodialysis patients and displays a direct correlation with factors which are age related except diabetes mellitus. Thus, the presence of isolated anti-HBc should prompt the clinician to evaluate a possible OHB infection especially when it is detected in conjunction with a history of diabetes mellitus |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Nefrología, Salud pública, Virus de la hepatitis B, Hemodiálisis, Anticuerpos, Prevalencia |
| Keyword: | Gastroenterology, Nephrology, Public health, Hepatitis B virus, Hemodialysis, Antibodies, Prevalence |
| Full text: | Texto completo (Ver PDF) |
