| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415039 |
| ISSN: | 1665-2681 |
| Authors: | Rafiq, Nila1 Stepanova, Maria2 Lam, Brian1 Nader, Fatema1 Srishord, Manirath1 Younossi, Zobair M1 |
| Institutions: | 1Inova Fairfax Hospital, Center for Liver Diseases, Falls Church, Virginia. Estados Unidos de América 2Inova Health System, Betty and Guy Beatty Center for Integrated Research, Falls Church, Virginia. Estados Unidos de América |
| Year: | 2014 |
| Season: | Ene-Feb |
| Volumen: | 13 |
| Number: | 1 |
| Pages: | 60-64 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Chronic liver disease (CLD) is becoming a major cause of mortality in patients who are positive with human immunodeficiency virus (HIV). Our aim was to assess the prevalence of CLD in HIV+ individuals. Material and methods. We utilized the National Health and Nutrition Examination Survey (1999-2008) to assess the association of CLD with HIV infection. In eligible participants (18-49 years), HIV infection was defined as positive anti-HIV by enzyme immunoassay further confirmed by Western blot. The diagnosis of CLD included chronic hepatitis C (CH-C), alcohol-related liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Clinic-demographic and laboratory parameters were used to assess differences between those with and without HIV infection. Results. 14,685 adults were included. Of those, 0.43 ± 0.08% were HIV-positive and 13.8% had evidence of CLD, including 26.3% in HIV-positive individuals and 13.7% in HIV-negative controls (p = 0.0341). In the U.S. population, independent predictors of CLD included HIV positivity [OR = 1.96 (1.02-3.77), p = 0.04], older age [OR = 1.03 (1.02-1.03), p < 0.0001], male gender [OR = 2.15 (1.89- 2.44), p < 0.0001] and obesity [OR = 2.10 (1.82-2.43), p < 0.0001], while African American race/ethnicity was associated with lower risk for CLD [OR = 0.68 (0.58-0.80), p < 0.0001]. Conclusions. CLD is common in HIV positive individuals. With successful long term treatment of HIV, management of CLD will continue to remain very important in these patients |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Inmunología, Infecciones virales, VIH, Factores predictivos, Enfermedad hepática crónica |
| Keyword: | Medicine, Gastroenterology, Immunology, HIV, Predictive factors, Chronic liver disease |
| Full text: | Texto completo (Ver PDF) |
