| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000407489 |
| ISSN: | 1665-2681 |
| Authors: | Coelho, Rosa1 Goncalves, Regina1 Carneiro, Fatima2 Fernandes, Margarida2 Lopes, Joanne2 Guimaraes, Susana2 Macedo, Guilherme1 |
| Institutions: | 1Centro Hospitalar Sao Joao, Departamento de Gastroenterologia, Porto. Portugal 2Centro Hospitalar Sao Joao, Departamento de Patologia, Porto. Portugal |
| Year: | 2016 |
| Season: | Jul-Ago |
| Volumen: | 15 |
| Number: | 4 |
| Pages: | 598-603 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico |
| English abstract | Hepatocellular adenomas (HCAs) are benign liver tumors recently characterized into 4 different types according to genetic, pathological and clinical features. The prognosis is not well established yet and malignant transformation has been recently associated with β-catenin activation. We aimed to describe a case of a pigmented HCA with β-catenin nuclear expression and inflammatory features and to review the cases of pigmented HCAs in the literature. We report a case of a young female patient without contraceptive use, with a liver tumor diagnosis. Liver biopsy revealed diffuse expression of β-catenin and a partial hepatic resection was performed. The histologic analysis revealed a hepatocellular tumor composed of uniform trabeculae of hepatocytes and solid areas, the later with a significant amount of black pigment highlighted by Masson-Fontana stain. Immunohistochemistry showed co-expression of C-reactive protein and serum amyloid A in the tumor. Literature review revealed that pigmented HCAs, previously reported as dark adenomas, are rare tumors. In HCAs, the presence of β-catenin activation should be searched for due to the higher risk of malignant transformation in hepatocarcinoma. We describe a pigmented HCA with β-catenin nuclear expression and inflammatory features being the fifth case reported so far |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Adenoma hepatocelular, Beta catenina, Glutamina sintetasa |
| Keyword: | Medicine, Gastroenterology, Hepatocellular adenoma, Beta catenin, Glutamine synthetase |
| Full text: | Texto completo (Ver PDF) |
