| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415669 |
| ISSN: | 1665-2681 |
| Authors: | Jiang, Qian1 Jiang, Gang1 Shi, Ke-qing2 Cai, Hong1 Wang, Yi-xin1 Zheng, Ming-hua2 |
| Institutions: | 1Second People’s Hospital of Sichuan Province, Department of Pharmacy, Chengdu, Sichuan. China 2First Affiliated Hospital of Wenzhou Medical University, Liver Research Center, Wenzhou, Zhejiang. China |
| Year: | 2013 |
| Season: | Sep-Oct |
| Volumen: | 12 |
| Number: | 5 |
| Pages: | 803-809 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | To systematically review the effect of Acetyl-L-Carnitine in patients with hepatic encephalopathy. Material and methods. Design: systematic review and meta-analysis. Data sources: The Cochrane Library, MEDLINE, EMBASE.com, Science Citation Index, Google search and the China Biological Medicine Database to June 2012. Review methods: randomized placebo controlled trials of Acetyl-L-Carnitine in patients with hepatic encephalopathy assessing whether Acetyl-L-Carnitine an effective therapy or not. No language restrictions were applied. Two reviewers independently extracted data and assessed quality. Results. 7 methodologically sound randomized controlled trials were identified involving 660 participants with hepatic encephalopathy, totaling 249 with subclinical hepatic encephalopathy, 189 with West Haven grade 1, 162 with West Haven grade 2 and 60 with West Haven grade 3. Acetyl-L-Carnitine was effective to improve serum ammonia level (weighted mean difference 25.90, 95% confidence intervals 20.89 to 30.91, P < 0.05) and the number connection test completion time (weighted mean difference 16.62, 95% confidence intervals 9.88 to 23.36, P < 0.05). The outcome was consistent in subgroup analyses. No publication bias was detected. Adverse events were reported infrequently and were minor. Conclusions. Acetyl-L-Carnitine is promising as an effective and tolerable treatment for hepatic encephalopathy that associated with improved serum ammonia levels and the number connection test |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Gastroenterología, Encefalopatía hepática, Acetil-L-carnitina, Medicina basada en evidencias |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Hepatic encephalopathy, Acetyl-L-carnitine, Evidence based medicine |
| Full text: | Texto completo (Ver PDF) |
