Revista: | Annals of hepatology |
Base de datos: | PERIÓDICA |
Número de sistema: | 000409081 |
ISSN: | 1665-2681 |
Autores: | Saad, Nael1 Rude, Mary Katherine2 Darcy, Michael1 Hanin, Jacob B2 Wentworth, Ashley1 Korenblat, Kevin M2 |
Instituciones: | 1Washington University, Mallinckrodt Institute of Radiology, Saint Louis, Missouri. Estados Unidos de América 2Washington University, School of Medicine, Saint Louis, Missouri. Estados Unidos de América |
Año: | 2016 |
Volumen: | 15 |
Número: | 2 |
Paginación: | 215-221 |
País: | México |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Aplicado, descriptivo |
Resumen en inglés | The role of age as a predictor of mortality after transjugular intra hepatic portosystemic shunt (TIPS) is controversial. Age has been found to be an important predictor of post-TIPS mortality in some, but not all, studies and is not a component of the MELD score. The purpose of this study was to compare the 90-day survival of subjects with cirrhosis age ≥ 70 years with younger subjects undergoing TIPS. Material and methods. Material and methods. A Material and methods. database of adult with cirrhosis undergoing TIPS from 2003- 2011 was analyzed. The primary endpoint was survival 90-days post-TIPS. Survival was analyzed by the Kaplan-Meier method and proportional hazard modeling. Results. Results. 539 Results. subjects met study criteria. 474 (88%) were between the ages of 24-69 and 65 (12%) were age 70-89 years. The groups were similar with respect to the indication for TIPS, mean MELD score and distribution of MELD score. Survival 90-days post-TIPS was 60% in the older cohort compared with 85% in the younger cohort (p < 0.001). Proportional hazards modeling controlled for comorbidities identified age ≥ 70 and MELD score as predictors of early post-TIPS survival. The hazard ratio associated with age increased monotonically, became significant at age ≥ 70 years (HR 3.22; 95% CI 1.81-5.74; p < 0.001) and exceeded the effect of MELD on survival. Age ≥ 70 was associated with reduced survival within 90 days following TIPS. The findings from this study indicate that age is a relevant consideration in assessing the early mortality risk of TIPS |
Disciplinas: | Medicina |
Palabras clave: | Gastroenterología, Sistema cardiovascular, Cirrosis hepática, Hipertensión portal, Derivación intrahepática portosistémica transyugular, Ancianos, Sobrevivencia |
Keyword: | Medicine, Cardiovascular system, Gastroenterology, Liver cirrhosis, Portal hypertension, Transjugular intrahepatic portosystemic shunt, Aged, Survival |
Texto completo: | Texto completo (Ver PDF) |