| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415640 |
| ISSN: | 1665-2681 |
| Authors: | Soresi, Maurizio1 Vecchi, Valentina Li1 Giannitrapani, Lydia1 Carlo, Paola Di2 Mazzola, Giovanni3 Colletti, Pietro3 Spada, Emanuele La1 Vizzini, Giovanni4 Montalto, Giuseppe1 |
| Institutions: | 1Universita di Palermo, Dipartimento Biomedico di Medicina Interna, Palermo, Sicilia. Italia 2Universita di Palermo, Dipartimento di Scienze delle Promozione della Salute, Palermo, Sicilia. Italia 3Policlinico Paolo Giaccone-Palermo, Sezione di Malattie Infettive, Palermo, Sicilia. Italia 4University of Pittsburgh Medical Center, Mediterranean Institute for Transplantation and Advanced Specialized Therapies, Palermo, Sicilia. Italia |
| Year: | 2013 |
| Season: | Sep-Oct |
| Volumen: | 12 |
| Number: | 5 |
| Pages: | 740-748 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Conflicting data have been reported on the prevalence of liver steatosis, its risk factors and its relationship with fibrosis in patients with human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infection or with HCV mono-infection. Aim. The study aims were to assess steatosis prevalence and its risk factors in both HCV groups. We also evaluated whether steatosis was linked with advanced fibrosis. Sixty-eight HIV/HCV co-infected and 69 HCV mono-infected patients were consecutively enrolled. They underwent liver ultrasonography and transient elastography. Bright liver echo-pattern was used to diagnose steatosis; advanced fibrosis was defined as liver stiffness ≥ 9.5 kPa and FIB-4 values ≥ 3.25. The optimal stiffness cut-off according to FIB-4 ≥ 3.25 was evaluated by ROC analysis. Results. No significant difference was found in steatosis-prevalence between mono- and co-infected patients (46.3 vs. 51.4%). Steatosis was associated with triglycerides and impaired fasting glucose/diabetes in HCV mono-infected, with lipodystrophy, metabolic syndrome, total-cholesterol and triglycerides in co-infected patients. Stiffness ≥ 9.5 was significantly more frequent in co-infection (P < 0.003). Advanced fibrosis wasn’t significantly associated with steatosis. The area under the ROC curve was 0.85 (95% CI 0.79-0.9). On multivariate analysis steatosis was associated with triglycerides in both HCV mono- and co-infected groups (P < 0.02; P < 0.03). Conclusion. Although steatosis was common in both HCV mono- and co-infected patients, it was not linked with advanced fibrosis. Triglycerides were independent predictors of steatosis in either of the HCV-groups. Dietary interventions and lifestyle changes should be proposed to prevent metabolic risk factors |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Gastroenterología, VIH, Virus de la hepatitis C, Fibrosis hepática, Esteatosis, Elastografía transitoria |
| Keyword: | Medicine, Diagnosis, Gastroenterology, HIV, Hepatitis C virus, Liver fibrosis, Steatosis, Transient elastography |
| Full text: | Texto completo (Ver PDF) |
