| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000415683 |
| ISSN: | 1665-2681 |
| Authors: | Wong, Grace Lai-Hung1 Vergniol, Julien2 Lo, Peter3 Wong, Vincent Wai-Sun1 Foucher, Juliette2 Le Bail, Brigitte4 Choi, Paul Cheung-Lung5 Chermak, Faiza2 Leung, Kwong-Sak3 Merrouche, Wassil2 Chan, Henry Lik-Yuen6 Ledinghen, Victor de2 |
| Institutions: | 1The Chinese University of Hong Kong, Institute of Digestive Disease, Hong Kong. China 2Centre Hospitalier Universitaire de Bordeaux, Hopital Haut-Leveque, Pessac, Bordeaux. Francia 3The Chinese University of Hong Kong, Department of Computer Science and Engineering, Hong Kong. China 4Universite Bordeaux Segalen, Institut National de la Sante et de la Recherche Medicale, Bordeaux, Gironde. Francia 5The Chinese University of Hong Kong, Department of Anatomical and Cellular Pathology, Hong Kong. China 6Prince of Wales Hospital, Department of Medicine and Therapeutics, Hong Kong. China |
| Year: | 2013 |
| Season: | Jul-Ago |
| Volumen: | 12 |
| Number: | 4 |
| Pages: | 402-412 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Limited studies have aimed to define the cut-offs of XL probe (XL cut-offs) for different stages of liver fibrosis, whereas those of M probe (M cut-offs) may not be applicable to XL probe. We aimed to derive appropriate XL cut-offs in overweight patients. Patients with liver stiffness measurement (LSM) by both probes were recruited. XL cut-offs probe for corresponding M cut-offs were derived from an exploratory cohort, and subsequently validated in a subgroup patients also underwent liver biopsy. The diagnostic accuracy of XL cut-offs to diagnose advanced fibrosis was evaluated. Results. Total 517 patients (63% male, mean age 58) who had reliable LSM by both probes were included in the exploratory cohort. There was a strong correlation between the LSM by M probe (LSM-M) and LSM by XL probe (LSM-XL) (r² = 0.89, p < 0.001). A decision tree using LSM-XL was learnt to predict the 3 categories of LSM-M (< 6.0kPa, 6.0-11.9kPa and ≥ 12.0kPa), and XL cut-offs at 4.8kPa and 10.7kPa were identified. These cut-offs were subsequently validated in a cohort of 147 patients who underwent liver biopsy. The overall accuracy was 89% among 62 patients whose LSM-XL < 4.8kPa or ≥ 10.7kPa. These cut-offs would have avoided under-staging of fibrosis among patients with body mass index (BMI) > 25-30 kg/m2 but not > 30 kg/m2. Conclusions. XL cut-offs at 4.8kPa and 10.7kPa were the best estimates of 6.0kPa and 12.0kPa of M probe for patients with BMI > 25-30 kg/m2. Patients with BMI > 30 kg/m² might use M probe cut-offs for XL probe |
| Disciplines: | Medicina |
| Keyword: | Diagnóstico, Gastroenterología, Cirrosis hepática, Fibrosis hepática, Pruebas diagnósticas, Elastografía transitoria |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Liver cirrhosis, Liver fibrosis, Diagnostic tests, Transient elastography |
| Full text: | Texto completo (Ver PDF) |
