| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000418423 |
| ISSN: | 1665-2681 |
| Authors: | Urbanek,Petr1 Lenícek, Martin2 Muchova, Lucie2 Subhanova, Iva2 Dusek, Ladislav3 Kaspríkova, Nikola1 Hrabal, Petr4 Bruha, Radan1 Vítek, Libor1 |
| Institutions: | 1Charles University, 1st. Faculty of Medicine, Praga. República Checa 2Charles University, Institute of Clinical Biochemistry, Praga. República Checa 3Masaryk University, Faculty of Medicine, Brno, Lednice. República Checa 4Central Military Hospital Prague, Department of Pathology, Praga. República Checa |
| Year: | 2011 |
| Season: | Oct-Dic |
| Volumen: | 10 |
| Number: | 4 |
| Pages: | 445-451 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1), both enzymes involved in bilirubin homeostasis, play an important role in oxidative stress defense. Objective. To assess the effect of promoter variations of HMOX1 and UGT1A1 genes on the progression of fibrosis in patients chronically infected with the hepatitis C virus (HCV). The study was performed on146 chronic HCV infection patients, plus 146 age- and sex-matched healthy subjects. The (GT)n and (TA)n dinucleotide variations in HMOX1 and UGT1A1 gene promoters, respectively, were determined by fragment analysis in all subjects. Results. No differences were found in the frequencies of each particular allele of both genes, between HCV patients and a control group (p > 0.05). Furthermore, no association was detected (p > 0.05) between either the HMOX1 or the UGT1A1 promoter variants and the individual histological stages of liver disease in the HCV positive patients. Finally, no differences in the HMOX1 and UGT1A1 genotype prevalence rates were found between pre-cirrhotic and cirrhotic patients (p > 0.05). Based on our data, microsatellite variations in the HMOX1 and UGT1A1 genes are not likely to protect from progression of liver disease in patients with chronic hepatitis C |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Genética, Hepatitis crónica, Hepatitis C, Estrés oxidativo, Bilirrubina, Hemo oxigenasa, Promotores genéticos, Variabilidad genética, Fibrosis hepática |
| Keyword: | Gastroenterology, Genetics, Chronic hepatitis, Hepatitis C, Oxidative stress, Bilirubin, Hemo oxygenase, Genetic promoters, Genetic variability, Liver fibrosis |
| Full text: | Texto completo (Ver PDF) |
