| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000413414 |
| ISSN: | 1665-2681 |
| Authors: | Khositseth, Anant1 Treepongkaruna, Suporn1 Khemakanok, Khemika1 Teeraratkul, Sumate1 Pansrimangkorn, Vichai1 Thirapattaraphan, Chollasak1 Leelaudomlipi, Surasak1 |
| Institutions: | 1Mahidol University, Ramathibodi Hospital, Bangkok, Phra Nakhon. Tailandia |
| Year: | 2016 |
| Season: | Ene-Feb |
| Volumen: | 15 |
| Number: | 1 |
| Pages: | 47-52 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Chronic liver disease (CLD) can cause hepatopulmonary syndrome (HPS), defined as triad of liver disease, hypoxemia, and intrapulmonary vascular dilation (IPVD). The aim of this study was to determine the evidence of IPVD in a cohort of pediatric patients with CLD pre- and post-liver transplantation (LT). Material and methods. Material and methods. Material and methods. All pediatric patients with CLD listed for LT were studied. Pulse oxygen saturation (SpO2 ), technetium-99m–labeled macroaggregated albumin (99mTc- MAA) perfusion scan (positive test: uptake of the isotope ≥ 6% in the brain), and echocardiography with saline bubble test (SBT) were performed. SBT was re-evaluated at 3-6 months after LT. Grading of SBT included grade 0 (no bubble), I (1-9 bubbles), grade II (10-20 bubbles), and grade III (> 20 bubbles). Results. Results. Results. Eighteen patients, median age 22.5 months (8-108), were enrolled. Most had biliary atresia (77.8%). Pre-LT, all patients had SpO2 of 100% and none had positive 99mTc- MAA perfusion scan. Two patients (11%) had negative SBT (grade 0), 1 (5.5%) had grade I, 3 (16.5%) had grade II, and 12 (67%) had grade III, respectively. Post-LT SBT became negative in all survivors (n = 16), (p = 0.0001). Conclusions. Conclusions. Conclusions. Most cirrhotic children in this cohort study had evidence of IPVD by positive SBT. However, none of these met the criteria for diagnosis of HPS. This evidence of IPVD subsided after LT |
| Disciplines: | Medicina |
| Keyword: | Cirugía, Gastroenterología, Sistema cardiovascular, Cirrosis hepática, Trasplante de hígado, Ecocardiografía, Cianosis, Dilatación vascular, Niños |
| Keyword: | Medicine, Cardiovascular system, Gastroenterology, Surgery, Liver cirrhosis, Liver transplantation, Echocardiography, Cyanosis, Vascular dilation, Children |
| Full text: | Texto completo (Ver PDF) |
