Inflammation is not the cause of an elevated serum ferritin in non-alcoholic fatty liver disease
Document title: Inflammation is not the cause of an elevated serum ferritin in non-alcoholic fatty liver disease
Journal: Annals of hepatology
Database: PERIÓDICA
System number: 000414223
ISSN: 1665-2681
Authors: 1
1
1
Institutions: 1Western University, University Hospital, London, Ontario. Canadá
Year:
Season: May-Jun
Volumen: 13
Number: 3
Pages: 353-356
Country: México
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract In non-alcoholic fatty liver disease (NALFD), it has often been assumed that an elevation in serum ferritin is likely related to inflammation rather than iron overload. Material and methods. Patients referred with NAFLD were entered into a clinical study of phlebotomy therapy. A liver biopsy with liver iron concentration was done at entry and 6 months after phlebotomy (n = 56) until the patient had a low serum ferritin or developed anemia. Serum ferritin was compared to liver iron concentration, ESR, CRP, BMI and grade of inflammation on liver biopsy. Results. Iron removed by phlebotomy in NAFLD correlated with the decrease in serum ferritin (r = 0.57, p = 0.0014) and liver iron concentration (r = 0.57, p = 0.0013). There was no significant correlations between serum ferritin and ESR, CRP or grade of liver inflammation. Conclusions. Serum ferritin is related to liver iron storage in NAFLD and decreasing body iron stores by phlebotomy is reflected by an appropriate decrease in serum ferritin. Inflammation is not the cause of the elevated serum ferritin in fatty liver disease
Disciplines: Medicina
Keyword: Gastroenterología,
Esteatohepatitis no alcohólica,
Hemocromatosis,
Hígado graso,
Ferritina sérica,
Fisiopatología
Keyword: Medicine,
Gastroenterology,
Non-alcoholic steatohepatitis,
Hemochromatosis,
Fatty liver,
Serum ferritin,
Physiopathology
Full text: Texto completo (Ver PDF)