| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000390967 |
| ISSN: | 1665-2681 |
| Authors: | Muñoz Espinosa, Linda E1 Trujillo Trujillo, María E2 Martínez Macías, Roberto F1 Panduro, Arturo2 Rivas Estilla, Ana María1 Fierro, Nora A2 Silvera Linares, Ana L1 Torres Valadez, Rafael2 Cordero Pérez, Paula1 González Aldaco, Karina2 Chen López, Carlos Y1 José Abrego, Alexis2 Zúñiga Noriega, Jaime Raúl1 Gutiérrez Ruiz, María C3 Roman, Sonia2 |
| Institutions: | 1Universidad Autónoma de Nuevo León, Hospital Universitario Dr. José Eleuterio González, Monterrey, Nuevo León. México 2Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco. México 3Universidad Autónoma Metropolitana, Departamento de Ciencias de la Salud, Iztapalapa, Distrito Federal. México |
| Year: | 2015 |
| Season: | Sep-Oct |
| Volumen: | 14 |
| Number: | 5 |
| Pages: | 642-651 |
| Country: | México |
| Language: | Inglés |
| Document type: | Estadística o encuesta |
| Approach: | Analítico |
| English abstract | The evolving pattern of HCV genotypes (GTs) and risk factors (RFs) in HCV-infected patients in Mexico is poorly understood. This study aimed to access the temporal trend of HCV GTs and RFs in HCV patients from two care centers. Material and methods. Chronic HCV patients [177 and 153 patients from the Northeast (NE) and Central West (CW) regions, respectively] were selected. Baseline features were demographics, date of birth (DOB), blood transfusion before 1992 (BTb1992), RFs, sexual promiscuity (SP), dental procedure (DP), injection drug use (IDU), viral load (VL), GTs, cirrhosis status and antiviral therapy (AT). Data were analyzed by Chi-square test for trends, unpaired T-test, and logistic regression. Results. HCV GT distribution was: GT1, 67%; GT2, 16%; GT3, 12% and GT4, 1%. RFs were BTb1992, 56%; surgeries, 56%; tattooing, 18% and IDU, 16%. GT1a mostly prevailed in CW than NE patients. GT1b, surgeries, BTb1992 and cirrhosis were more prevalent in older patients (p < 0.05); GT3, male gender IDU, SP, and tattooing showed an upward trend as younger were the patients in both regions (p < 0.05), contrariwise to the prevalence of GT1b. BTb1992 and surgeries were seen in elder women; BTb1992 was an independent RF for GT1. Age ≥ 50 years old, GT1 and exposure to AT (p < 0.05) were associated with cirrhosis. Conclusion. GT1a prevalence in CW Mexico remained stable, whereas GT3 increased and GT1b decreased in younger patients in both regions, along with associated RFs. Further regional molecular epidemiology and RF analyses are required in order to avoid the dissemination of new cases of HCV infection |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Microbiología, Salud pública, Hepatitis C, Epidemiología molecular, Grupos de riesgo, Terapia antiviral, Cirrosis, Factores de riesgo |
| Keyword: | Medicine, Gastroenterology, Microbiology, Public health, Hepatitis C, Molecular epidemiology, Risk groups, Antiviral therapy, Cirrhosis, Risk factors |
| Full text: | Texto completo (Ver PDF) |
