| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000416157 |
| ISSN: | 1665-2681 |
| Authors: | Machado, Adriana Goncalves da Silva1 Fleck-Junior, Alfeu de Medeiros2 Marroni, Claudio Augusto1 Zanotelli, Maria Lucia2 Cantisani, Guido2 Brandao, Ajacio Bandeira de Melo1 |
| Institutions: | 1Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, Rio Grande do Sul. Brasil 2Complexo Hospitalar Santa Casa de Misericordia de Porto Alegre, Porto Alegre, Rio Grande do Sul. Brasil |
| Year: | 2013 |
| Volumen: | 12 |
| Number: | 3 |
| Pages: | 440-447 |
| Country: | México |
| Language: | Inglés |
| Document type: | Estadística o encuesta |
| Approach: | Analítico |
| English abstract | Model for end-stage liver disease (MELD) is an accurate predictor of mortality in patients with cirrhosis, and has been used on liver allocation in Brazil since 2006. However, its impact on organ allocation, waiting list and post-transplant mortality is still poorly characterized. This study aimed to assess the impact of implementation of the MELD system on liver allocation and mortality after liver transplantation (LT) in Southern Brazil. Material and methods. Adult patients with chronic liver disease on the waiting list for primary deceased-donor LT were divided into two cohorts (pre-and post-MELD implementation) according to the date of waiting list placement. Disease severity, as assessed by MELD score at placement, was similar in both cohorts. Patients were followed for at least 18 months to assess the outcomes of interest (death/LT). Results. Higher MELD scores correlated with waiting list mortality, which increased 20% with each additional point (HR 1.2; 95%CI 1.14-2.26; p < 0.001). Waiting list mortality was 30.9% before and 21.7% after MELD implementation (nonsignificant). Transplant rate increased after MELD implementation (52 vs. 40%, p = 0.002). After excluding patients with hepatocellular carcinoma, mean MELD scores at LT were significantly higher in the MELD era (p < 0.01). There was no significant correlation between MELD scores at LT and post-LT survival. During 18-month follow-up, post-LT mortality rate was 25.4% before and 20% after MELD implementation (nonsignificant). Conclusion. MELD implementation was associated with a reduction in waiting list mortality. Although sicker patients received LT in the MELD era, post-transplant survival was similar in both periods |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Diagnóstico, Pronóstico, Enfermedad hepática terminal, Trasplantes, Hígado, Mortalidad, Sobrevivencia, Cirrosis |
| Keyword: | Gastroenterology, Diagnosis, Prognosis, End-stage liver disease, Liver, Transplantation, Mortality, Survival, Cirrhosis |
| Full text: | Texto completo (Ver PDF) |
